Possible involvement of mu-opioid receptors in effect of lithium on inhibitory avoidance response in mice

Journal of Psychopharmacology
M-R ZarrindastS Ahamadi

Abstract

In the present study, effects of intracerebroventricular (i.c.v.) injections of mu-opioid receptor agonist and antagonist on lithium state-dependency were investigated. For memory assessment, a one-trial step-down inhibitory avoidance task was used in adult male NMRI mice. Intraperitoneal (i.p.) administration of lithium (10 mg/kg) after training impaired memory when retrieval was tested 24 h later. The memory impairment was reversed by pretest administration of the same dose of lithium, suggesting state-dependency induced by lithium. In addition, i.c.v. administration of both lithium (2 and 4 microg/mouse, i.c.v.) and morphine (3 and 6 microg/mouse, i.c.v.) before the test reversed memory impairment induced by post-training lithium (10 mg/kg, i.p.). On the other hand, pretest administration of naloxone (1 and 2 mg/kg) which had no effects alone on inhibitory avoidance response, prevented the improving effects of both morphine (3 microg/mouse, i.c.v.) and lithium (2 microg/mouse, i.c.v.) on memory retrieval. The results suggest that the mu-opioid receptors in the central nervous system may be involved in the retrieval of lithium state-dependent learning.

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Citations

Jan 13, 2010·Neurobiology of Learning and Memory·Nasrin-Sadat AzamiMohammad-Reza Zarrindast
May 20, 2009·Neurobiology of Learning and Memory·Mohammad NasehiMohammad Reza Zarrindast
Jul 9, 2008·European Journal of Pharmacology·Mohammad Reza ZarrindastShamseddin Ahmadi
Jan 24, 2009·Journal of Psychopharmacology·M RezayatM R Zarrindast
Oct 4, 2011·Journal of Psychopharmacology·Mohammad NasehiMohammad Reza Zarrindast
Oct 20, 2011·Pharmacology, Biochemistry, and Behavior·Hamid R BanafsheGholam A Hamidi
Oct 2, 2009·Peptides·Richard J Bodnar

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