PMID: 6404652May 2, 1983Paper

Possible involvement of NADPH-cytochrome P450 reductase and cytochrome b5 on beta-ketostearoyl-CoA reduction in microsomal fatty acid chain elongation supported by NADPH

FEBS Letters
M NagaoY Imai

Abstract

The chain elongation products from [2-14C]malonyl-CoA and palmitoytl-CoA by rat liver microsomes initiated by NADPH were found mainly to be 18:1 and 18:0. When anti-NADPH-cytochrome P450 reductase or anti-cytochrome b5 immunoglobulin G were included in this system, not only was the overall chain elongation significantly suppressed, but also a new radioactive product, which was identified as 2-heptadecanone derived from an intermediate beta-ketostearate, is accumulated depending upon the amounts of IgG added. These results suggest that NADPH-cytochrome P450 reductase and cytochrome b5 participate in the conversion from beta-ketostearoyl-CoA to beta-hydroxystearoyl-CoA, which is the first reductive step of the microsomal chain elongating system.

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Citations

Feb 26, 1991·Biochimica Et Biophysica Acta·N DemirkapiD Ghesquier
Jan 1, 1992·Progress in Lipid Research·D L CintiS K Suneja
Jul 20, 2007·Fundamental & Clinical Pharmacology·Christa E FlückAmit V Pandey
Mar 29, 2013·PloS One·William R WikoffUNKNOWN Pharmacometabolomics Research Network
Aug 15, 1984·Biochimica Et Biophysica Acta·S Yoshida, M Takeshita
Feb 1, 1989·Archives of Biochemistry and Biophysics·J J BessouleC Cassagne
Aug 2, 2005·Archives of Biochemistry and Biophysics·F Peter Guengerich

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