Possible involvement of nitric oxide in morphine-induced miosis and reduction of intraocular pressure in rabbits

European Journal of Pharmacology
Vincenza BonfiglioFilippo Drago

Abstract

The role of mu3 opioid receptors in morphine-induced intraocular pressure (IOP) lowering effect and miosis was evaluated in conscious, dark-adapted New Zealand white (NZW) rabbits using a masked-design study. IOP and pupil diameter (PD) measurements were taken at just before and 0.5, 1, 2, 4, 6 h after monolateral instillation of morphine (10, 50 and 100 microg/30 microl) as compared to vehicle administered in the contralateral eye. Morphine-induced ocular effects were challenged by a pre-treatment with the non-selective opioid receptor antagonist, naloxone (100 microg/30 microl), the nitric oxide synthase inhibitor, N(omega)-nitro-L-arginine methyl ester (L-NAME, 1%, 30 microl), or the non-selective mu3 opioid receptor inhibitor, reduced L-glutathione (GSH, 1%, 30 microl). Morphine induced a dose-dependent decrease in IOP and PD. Pre-treatment with naloxone totally prevented morphine-induced decrease in IOP and miosis. Ocular administration of L-NAME or GSH alone failed to affect IOP or PD of NZW rabbits. However, pre-treatment with either drugs significantly reduced, but not totally prevented ocular effects of morphine. These results suggest that biochemical mechanisms related to nitric oxide release are involved, at least in...Continue Reading

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Citations

Sep 29, 2011·Pflügers Archiv : European journal of physiology·Noboru Toda, Megumi Nakanishi-Toda
Nov 19, 2009·Journal of Anesthesia·Noboru TodaHiroshi Toda
Mar 22, 2008·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Shahid Husain, David E Potter
Feb 13, 2010·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Edoardo StagniFilippo Drago
Jun 27, 2009·Experimental Eye Research·Juanita Dortch-Carnes, Karen Russell Randall
Oct 24, 2007·Peptides·Richard J Bodnar
Nov 11, 2006·Experimental Eye Research·Juanita Dortch-Carnes, Karen Russell
Jan 13, 2021·International Journal of Molecular Sciences·Allison M CleymaetJozsef Vigh

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