Possible involvement of NO-mediated oxidative stress in induction of rat forestomach damage and cell proliferation by combined treatment with catechol and sodium nitrite

Archives of Biochemistry and Biophysics
Yuji IshiiMasao Hirose

Abstract

To clarify the mechanisms underlying forestomach carcinogenesis in rats by co-treatment with catechol and sodium nitrite (NaNO2), we investigated the involvement of oxidative stress resulting from reaction of the two compounds. Since generation of semiquinone radical, hydroxyl radical (*OH), and peroxynitrite (ONOO-) arose through the reaction of catechol with NO, we proposed that superoxide resulting from catechol oxidation reacted with excess NO, consequently yielding *OH via ONOO-. Male F344 rats were co-treated with 0.2% catechol in the diet and 0.8% NaNO2 in the drinking water for 2 weeks. Prior to occurrence of histological evidence indicating epithelial injury and hyperplasia, 8-hydroxydeoxyguanosine levels in forestomach epithelium significantly increased from 12 h together with appearance of immunohistochemically nitrotyrosine-positive epithelial cells. There were no remarkable changes in rats given each chemical alone. We conclude that oxidative stress due to NO plays an important role in induction of forestomach epithelial damage, cell proliferation, and thus presumably forestomach carcinogenesis.

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Citations

Apr 25, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yuichi KuroiwaAkiyoshi Nishikawa
Jun 21, 2014·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Hasan ÖzenOnur Atakişi
Jul 5, 2011·Archives of Biochemistry and Biophysics·Yusuke IwasakiHiroyuki Nakazawa
Jul 6, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tomoyasu ToyoizumiNaohide Kinae
Aug 15, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nathan S BryanPaolo Boffetta
Mar 4, 2014·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Hiroyuki Nakazawa

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