Possible involvement of XPA in repair of oxidative DNA damage deduced from analysis of damage, repair and genotype in a human population study

Mutagenesis
Mária DusinskáAndrew R Collins

Abstract

Participants in a study of occupational exposure to mineral fibres in Slovakia were analysed for the polymorphism 23A-->G in the DNA repair gene XPA. Of the 388 subjects, 239 were exposed to asbestos, stonewool or glass fibre; the rest were unexposed controls. Levels of DNA base alterations (oxidation and alkylation) in lymphocytes were measured using the comet assay with lesion-specific endonucleases. 8-oxoguanine DNA glycosylase (OGG1) DNA repair activity was measured, as incision activity of a lymphocyte extract on DNA containing the OGG1 substrate 8-oxoguanine. Presence of the A allele was associated with higher levels of DNA damage (sites sensitive to formamidopyrimidine DNA glycosylase, endonuclease III or 3-methyladenine DNA glycosylase II) as well as with higher activity of OGG1 repair enzyme. DNA base damage increased with age, showing highly significant correlations when the whole population or subgroups of the population were analysed. OGG1 repair activity also increased with age, but when analysed according to XPA genotype, the increase was observed only in those individuals with an A allele. Although XPA is known as a protein involved in nucleotide excision repair of UV-induced damage and bulky DNA adducts, it may ...Continue Reading

References

Jun 22, 1999·The Journal of Biological Chemistry·M Wakasugi, A Sancar
Feb 16, 2000·Gene·D P Batty, R D Wood
Jun 22, 2000·Human Mutation·O BasmaisonD Bozon
Nov 4, 2000·Journal of the National Cancer Institute·Q WeiM R Spitz
Aug 4, 2004·Mutation Research·Mária DusinskáSoterios Kyrtopoulos
Aug 4, 2004·Mutation Research·Mária DusinskáAndrew Collins

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Citations

Jul 30, 2009·Journal of Applied Genetics·E ZietkiewiczM Witt
May 21, 2013·Archives of Toxicology·Amaya Azqueta, Andrew R Collins
Dec 15, 2010·European Journal of Nutrition·Alexandra HorskaMaria Dusinska
Jun 28, 2007·Apoptosis : an International Journal on Programmed Cell Death·Hirofumi YamauchiHiroyuki Nakayama
Mar 8, 2012·Apoptosis : an International Journal on Programmed Cell Death·Suchada PhimsenNobuo Sakaguchi
Oct 13, 2009·Breast Cancer Research and Treatment·Lyndsay M MurrowStanley Lipkowitz
Dec 17, 2009·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Makoto NakanishiMidori Shimada
Oct 11, 2007·The British Journal of Nutrition·Serena GuarnieriPeter Møller
Nov 3, 2009·The British Journal of Nutrition·Sabine A S LangieFrederik J van Schooten
Sep 25, 2008·Lab on a Chip·J-F MillauS Sauvaigo
Jun 5, 2010·Mutagenesis·Mark D EvansMarcus S Cooke
Sep 8, 2010·Mutagenesis·Domenico PalliEugenia Dogliotti
May 17, 2011·Biochemistry. Biokhimii︠a︡·B PascucciE Dogliotti
Jan 26, 2013·Annual Review of Pathology·Gang LiuDavid W Kamp
Feb 23, 2013·Mechanisms of Ageing and Development·Kimberly D JacobMichele K Evans
Sep 21, 2011·Cancer Letters·Dimitrios Toumpanakis, Stamatios E Theocharis
Feb 22, 2011·International Journal of Hygiene and Environmental Health·Angela Di PietroAlberto Izzotti
Dec 18, 2009·Mutation Research·Sabine A S LangieRoger W L Godschalk
Nov 11, 2008·European Journal of Pharmacology·João P SilvaOlga P Coutinho
Dec 2, 2008·Mutation Research·Amaya AzquetaAndrew R Collins
Oct 11, 2008·Free Radical Biology & Medicine·Andrzej R TrzeciakMichele K Evans
Dec 7, 2007·Free Radical Biology & Medicine·Ana LloretGiovanni Pagano
Jul 31, 2007·Molecular Aspects of Medicine·Andrew R Collins, Isabel Gaivão
Jan 9, 2007·Toxicology Letters·Sabine A S LangieFrederik J van Schooten
Jan 26, 2011·Cell Biochemistry and Function·Asgeir BrevikAndrew Collins
Apr 19, 2012·International Journal of Cancer. Journal International Du Cancer·Dorota ButkiewiczMarzena Gawkowska-Suwińska
Jan 22, 2014·Cell Biochemistry and Function·Jorge Pinto SoaresIsabel Gaivão
Sep 25, 2010·Cellular & Molecular Biology Letters·Dorota ButkiewiczMarek Rusin
Dec 28, 2007·Radiation Research·Andrzej R TrzeciakMichele K Evans
Oct 25, 2011·Free Radical Biology & Medicine·Annie JensenPeter Møller
Sep 27, 2012·Free Radical Biology & Medicine·Eleonora ParlantiEugenia Dogliotti
Jun 6, 2018·International Journal of Molecular Sciences·Julita MachlowskaRobert Sitarz
Apr 3, 2020·International Journal of Molecular Sciences·Lucia Borszéková PulzováMiroslav Chovanec
Sep 7, 2020·Cancer Treatment Reviews·Ilaria Fuso NeriniMaurizio D'Incalci

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