Possible link between anaphylactoid reactions to anaesthetics and chemicals in cosmetics and biocides

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A Weston, E S Assem

Abstract

Binding-inhibition studies involving human IgE antibody to suxamethonium, SUX (from a patient with a near-fatal reaction), were performed with five different quaternary ammonium compounds (QAC): three common ingredients of cosmetics and two commonly used disinfectants, cetrimide and benzalkonium. All the five QAC showed immunological cross-reaction with SUX. In addition, at high concentrations, they released histamine from basophils of normal subjects. Thus, QAC may be both sensitizers and histamine releasers.

References

Dec 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·W Piotrowski, J C Foreman
Sep 1, 1982·Klinische Wochenschrift·D LangrehrS Agoston
Jun 1, 1983·The Journal of Allergy and Clinical Immunology·D VervloetJ Charpin
Jan 1, 1983·Annual Review of Pharmacology and Toxicology·D LagunoffG Read

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Citations

Feb 20, 2016·Archives of Environmental & Occupational Health·Agnieszka Anna Lipinska-OjrzanowskaJolanta Magdalena Walusiak-Skorupa

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Related Concepts

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Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

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