PMID: 6981747Jan 1, 1982Paper

Possible link between changes in plasma 24,25-dihydroxyvitamin D and healing of bone resorption in dialysis osteodystrophy

Metabolic Bone Disease & Related Research
G LambreyA Fournier

Abstract

Histomorphometric studies of bone biopsies were performed on 12 hemodialyzed patients before and after six months of treatment with 25-(OH) and 1 alpha-(OH) vitamin D3. Patients could be classified into three groups according to bone resorption: Group I with normal bone resorption; Group II with elevated initial bone resorption unresponsive to vitamin D treatment; group III with elevated initial bone resorption sensitive to vitamin D treatment. None of the patients had histological signs of osteomalacia. In Group I, plasma concentrations of 24,25-(OH)2D and the ratio of 24,25-(OH)2D to 25-(OH) D remained in the normal range throughout the study; in Group II these parameters were subnormal initially and did not increase above normal except in one case; in Group III, plasma concentrations of 24,25-(OH)2D were high before or at the beginning of vitamin D administration and normal at the time of the second biopsy and wide variations were observed in the ratio of 24,25-(OH)2D to 25-(OH)D. No difference was found between these last two groups with regard to the cumulative dose of vitamin D derivatives administered or the changes in plasma PTH, CT, calcium and phosphate. These observations suggest a specific regulation of plasma 24,25...Continue Reading

References

Mar 13, 1979·Calcified Tissue International·M LieberherrS Balsan
Jul 31, 1974·Clinica Chimica Acta; International Journal of Clinical Chemistry·M A PreeceE Kodicek
Mar 1, 1980·The Journal of Clinical Investigation·J M CanterburyE Reiss

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Citations

Nov 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R Vieth
Jul 5, 1984·The New England Journal of Medicine·L V Avioli, J G Haddad
Apr 1, 1985·Clinical Endocrinology·D F Guillard-CummingJ A Kanis

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