PMID: 6405441Jan 1, 1983Paper

Possible mechanism of digoxin-induced convulsions

Psychopharmacology
S K Kulkarni, A K Mehta

Abstract

Intraventricular (IVT) administration of digoxin (7.5 micrograms) induced 'popcorn-type' convulsions in rats. Though the convulsions looked similar to morphine-induced seizures, naloxone failed to antagonize these effects. Other anticonvulsants like phenobarbitone, ethosuximide, or GABAergic substances like piracetam and semicarbazide also had no protective effect against digoxin-induced convulsions. While calcium chloride potentiated these effects of digoxin, phenytoin, magnesium chloride, and potassium chloride treatment showed blocking actions. These observations suggest the involvement of Na/K-ATPase system in digoxin-induced convulsions. Clonidine and diazepam also provided protection against digoxin-induced convulsions through an unknown mechanism.

References

Sep 1, 1978·The Journal of Physiology·R H BrownD Noble
Mar 1, 1981·Clinical and Experimental Pharmacology & Physiology·M R Dzoljic, A L v d Poel-Heisterkamp
Jan 22, 1982·European Journal of Pharmacology·J PapanicolaouW J Louis

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Citations

Jul 1, 1993·Pharmacology & Toxicology·Y ChughP L Sharma
Aug 1, 1997·Seizure : the Journal of the British Epilepsy Association·C Y Tan, D F Weaver

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