PMID: 9535486Apr 16, 1998Paper

Possible mechanism of ECG features in patients with idiopathic ventricular fibrillation studied by heart model and computer simulation

Journal of Electrocardiology
O OkazakiD Wei

Abstract

The possible contribution of localized conduction delay and abnormal action potentials to ventricular fibrillation (VF) was studied by applying an anisotropic cardiac computer model to clinical cases of the Brugada-type electrocardiogram (ECG), which shows right bundle branch block (RBBB), a normal QT interval, ST-segment elevation, and late r' in leads V1 and V2. The anisotropic heart model was composed of 50,000 discrete units with a spatial resolution of 1.5 mm and was mounted in a human torso model. The longitudinal/transverse conduction velocity ratio was 3:1. For the normal ECG, a conduction velocity of 0.75 m/s was required. In the abnormal area of the right anterior epicardial wall, the conduction velocity was set at 0.2 m/s, with decreasing action potential amplitude and 10% prolonged action potential duration. The ECG features of ST-segment elevation and Brugada-type right bundle branch block pattern were simulated. The action potential duration was able to change dynamically with coupling interval of stimulation, with a ratio of 9% for normal ventricular muscle and 50% for Purkinje fibers. Five successive stimuli were applied to the left lateral epicardium 300 ms after the first sinus excitation, and sustained VF was...Continue Reading

Citations

Nov 3, 2000·Current Cardiology Reports·P BrugadaJ Brugada
Jan 8, 2016·Progress in Biophysics and Molecular Biology·Edward J Vigmond, Bruno D Stuyvers
Mar 3, 2009·Journal of Electrocardiology·Elena Ryzhii, Daming Wei
Oct 4, 2007·Progress in Biophysics and Molecular Biology·K H W J Ten Tusscher, A V Panfilov
Mar 3, 2004·Circulation·Raymond TukkieHanno L Tan

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