Possible mechanism underlying the association between height and vascular remodeling in elderly Japanese men

Oncotarget
Yuji ShimizuTakahiro Maeda

Abstract

Height is reported to be inversely associated with cardiovascular disease. And platelets play an important role in vascular remodeling by supporting CD34-positive cells. To clarify the association between height and platelet, we conducted a cross-sectional study of 219 elderly Japanese men. Since hemoglobin concentration is influenced by vascular remodeling activity, an analysis stratified by hemoglobin level was performed. An inverse association was seen between height and platelet count in subjects with a high hemoglobin concentration (≥ 14.5 g/dL), but not in subjects with a low hemoglobin concentration (< 14.5 g/dL). The standardized parameter estimates (β) were β = -0.22,p= 0.019 for subjects with high hemoglobin, and β = -0.01,p= 0.931 for subjects with low hemoglobin. We also found a positive association between platelets and carotid intima media thickness (CIMT) and circulating CD34-positive cells in subjects with high hemoglobin (partial correlation coefficient (r) = 0.21,p= 0.037 andr= 0.40,p=< 0.001), but not in subjects with low hemoglobin (r= 0.04,p= 0.710 andr= 0.06,p= 0.544). In subjects with a high hemoglobin concentration, platelets were inversely associated with height, and positively associated with CIMT and ...Continue Reading

References

Sep 23, 2000·Nature·A J Lusis
Jul 31, 2004·Journal of the American Society of Nephrology : JASN·Dierk H Endemann, Ernesto L Schiffrin
Apr 9, 2005·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Junmei Chen, José A López
Nov 24, 2005·Hematology·Jack M GuralnikVincent J Picozzi
Dec 3, 2005·The Journal of Clinical Investigation·Meinrad GawazAndreas E May
Nov 2, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Karin DaubMeinrad Gawaz
Aug 1, 2007·Journal of Thrombosis and Haemostasis : JTH·S LindemannM Gawaz
Sep 25, 2007·Clinical Orthopaedics and Related Research·Kevin GarvinAnn Berger
Oct 7, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Patrizia FerroniFiorella Guadagni
Jan 17, 2012·Atherosclerosis·Emilio OrtegaEmili Ros
Jul 23, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yuji ShimizuUNKNOWN CIRCS Investigators
Jul 24, 2014·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Yuji ShimizuTakahiro Maeda
Jan 29, 2016·Journal of Physiological Anthropology·Yuji ShimizuTakahiro Maeda
May 12, 2016·Environmental Health and Preventive Medicine·Yuji ShimizuTakahiro Maeda
Jul 5, 2016·Oncotarget·Yuji ShimizuTakahiro Maeda
Aug 27, 2016·Geriatrics & Gerontology International·Yuji ShimizuTakahiro Maeda
Oct 6, 2016·Aging·Yuji ShimizuTakahiro Maeda

❮ Previous
Next ❯

Citations

May 5, 2018·Environmental Health and Preventive Medicine·Yuji ShimizuTakahiro Maeda
May 3, 2019·Environmental Health and Preventive Medicine·Yuji ShimizuTakahiro Maeda
Feb 8, 2021·Environmental Health and Preventive Medicine·Yuji Shimizu, Takahiro Maeda

❮ Previous
Next ❯

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.