PMID: 6256669Nov 1, 1980

Possible mechanisms for inotropic actions of vanadate in isolated guinea pig and rat heart preparations

Naunyn-Schmiedeberg's Archives of Pharmacology
K TakedaI S Shieh


The mechanism of inotropic actions of vanadate studied in isolated, electrically stimulated atrial and ventricular muscle preparations of rat or guinea-pig heart. Vanadate produced a negative inotropic effect in guinea-pig left atrial preparations associated with a marked shortening of the action potential plateau. In guinea-pig papillary muscle, or rat atrial or ventricular muscle preparations, vanadate produced a positive inotropic effect, which was not affected by either propranolol, phentolamine or metiamide. The positive inotropic effect was observed when action potential duration was either increased or decreased. Inotropic concentrations of vanadate failed to significantly alter the ouabain-sensitive 86Rb+-uptake, an estimate of sodium pump activity, or tissue concentration of cyclic AMP in electrically stimulated preparations. In partially depolarized rat atrial preparations in which fast sodium channels were inactivated in the presence of a high concentration of K+ (22 mmol/l), vanadate restored electrical activity (calcium-dependent action potentials) and the contraction, similar to isoproterenol. This action of vanadate was abolished by Mn2+, a slow channel inhibitor, but not by tetrodotoxin. The characteristic of va...Continue Reading


Jul 28, 1977·Nature·L A Beaugé, I M Glynn
Oct 18, 1977·Biochemistry·L Josephson, L C Cantley
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Jan 1, 1969·Pflügers Archiv : European journal of physiology·O RougierE Coraboeuf
May 15, 1980·Biochemical Pharmacology·I HackbarthG Philipp


Jan 1, 1983·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·H Gesser, E Jørgensen
Apr 4, 2002·The Journal of General Physiology·Junyuan GaoRichard T Mathias
Apr 1, 1983·Archives internationales de physiologie et de biochimie·L Lambotte
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