PMID: 9524928Apr 3, 1998Paper

Possible mechanisms for the differential effects of high linoleate safflower oil and high alpha-linolenate perilla oil diets on platelet-activating factor production by rat polymorphonuclear leukocytes

Journal of Lipid Mediators and Cell Signalling
K Oh-hashiH Okuyama

Abstract

As compared with high dietary linoleate safflower oil, high dietary alpha-linolenate perilla oil decreased platelet-activating factor (PAF) production by nearly half in calcium ionophore (CaI)-stimulated rat polymorphonuclear leukocytes (PMN). In the CaI-stimulated PMN from the perilla oil group, the accumulated amount of arachidonate (AA) plus eicosapentaenoate (EPA) was 30% less and that of lyso-PAF was 50% less, indicating that the decreased availability of lyso-PAF is a factor contributing to the relatively low PAF production. Consistently, eicosatetraynoic acid (ETYA), a dual inhibitor of cyclooxygenase and lipoxygenase, increased free fatty acids (FFA) and decreased PAF production possibly by decreasing the availability of lyso-PAF. Although, leukotrienes (LTs) have been proposed to stimulate PAF production synergistically, a potent LTB4 receptor antagonist, ONO-4057, decreased the formation of free fatty acids and LTB4, but stimulated PAF production somewhat, indicating that LTB4 may not stimulate PAF production in PMN. Lysophospholipid-induced transacylase (CoA-independent transacylase) activity in PMN homogenates was 25-30% lower in the perilla oil group but no significant differences were observed in the lyso-PAF acet...Continue Reading

References

Jan 1, 1986·Annual Review of Biochemistry·D J Hanahan
Aug 1, 1987·Prostaglandins·P Braquet, M Rola-Pleszczynski
Feb 1, 1995·The Biochemical Journal·F Snyder
Jan 5, 1996·Biochimica Et Biophysica Acta·F H ChiltonJ D Winkler
Jun 11, 1996·Biochimica Et Biophysica Acta·D M StafforiniT M McIntyre
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER

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Citations

Nov 13, 2012·Journal of Food Science·Tingting ZhaoIn-Hwan Kim
Mar 29, 2002·Environmental and Molecular Mutagenesis·Masao HiroseTomoyuki Shirai
Jan 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Youssef RouphaelMaria Isabella Sifola

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