Possible mechanisms underlying slow component of V̇O2 on-kinetics in skeletal muscle

Journal of Applied Physiology
Bernard Korzeniewski, Jerzy A Zoladz

Abstract

A computer model of a skeletal muscle bioenergetic system is used to study the background of the slow component of oxygen consumption V̇O2 on-kinetics in skeletal muscle. Two possible mechanisms are analyzed: inhibition of ATP production by anaerobic glycolysis by progressive cytosol acidification (together with a slow decrease in ATP supply by creatine kinase) and gradual increase of ATP usage during exercise of constant power output. It is demonstrated that the former novel mechanism is potent to generate the slow component. The latter mechanism further increases the size of the slow component; it also moderately decreases metabolite stability and has a small impact on muscle pH. An increase in anaerobic glycolysis intensity increases the slow component, elevates cytosol acidification during exercise, and decreases phosphocreatine and Pi stability, although slightly increases ADP stability. A decrease in the P/O ratio (ATP molecules/O2 molecules) during exercise cannot also be excluded as a relevant mechanism, although this issue requires further study. It is postulated that both the progressive inhibition of anaerobic glycolysis by accumulating protons (together with a slow decrease of the net creatine kinase reaction rate) ...Continue Reading

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Citations

Jul 2, 2016·European Journal of Applied Physiology·Benjamin ChatelLaurent A Messonnier
Jun 25, 2016·Journal of Applied Physiology·Daniel A KeirJohn M Kowalchuk
Mar 24, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Paulo Cesar do Nascimento SalvadorBenedito Sérgio Denadai
Jun 13, 2020·The Journal of Physiology·Miles F BartlettJane A Kent
Jul 16, 2020·Pflügers Archiv : European journal of physiology·Alessandro L ColosioSilvia Pogliaghi
Sep 19, 2017·Frontiers in Physiology·Ana SousaGrégoire P Millet
May 28, 2017·Pflügers Archiv : European journal of physiology·J M O'ConnellB R MacIntosh
Feb 12, 2020·The Journal of Physiology·Miles F BartlettJane A Kent
Apr 26, 2019·Frontiers in Physiology·Manuel V Garnacho-CastañoJosé Luis Maté-Muñoz
Dec 17, 2020·International Journal of Environmental Research and Public Health·Claire A MolinariVéronique Billat
Oct 20, 2018·Journal of Strength and Conditioning Research·Manuel V Garnacho-CastañoJosé Luis Maté-Muñoz
May 20, 2021·Pflügers Archiv : European journal of physiology·Alessandro L ColosioSilvia Pogliaghi

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