PMID: 16503324Mar 1, 2006Paper

Possible metformin-induced hepatotoxicity

The American Journal of Geriatric Pharmacotherapy
Eiji Kutoh

Abstract

Metformin hydrochloride is widely used for the treatment of type 2 diabetes mellitus (DM-2). To date, only 2 cases of possible metformin-induced hepatotoxicity (acute hepatitis) have been reported worldwide. The aim of this article was to report a case of serious hepatotoxicity possibly associated with metformin use in an elderly patient with DM-2. After receiving metformin 500 mg/d for 3 weeks, a 73-year-old Japanese woman weighing 33.5 kg with poorly controlled DM-2 presented with fatigue, jaundice, nausea, vomiting, anorexia, and abdominal pain. Laboratory analysis showed severe hepatotoxicity (elevated aspartate and alanine aminotransferases [AST and ALT, respectively], alkaline phosphatase [ALP], and total bilirubin concentrations). The history, clinical findings, laboratory features, and clinical course of this case, as well as the pharmacologic profile of metformin, are presented. Immediate hospitalization and discontinuation of metformin treatment led to improvements in liver function (decreased AST, ALT, ALP, and total bilirubin concentrations) and resolution of the presented symptoms within 3 weeks. The probability of an adverse drug reaction (ADR), as assessed using the Naranjo ADR probability scale, in this case was...Continue Reading

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Citations

Jan 1, 2009·BMJ Case Reports·Raja Shekhar Reddy Sappati BiyyaniKhalil Korkor
Apr 12, 2013·Cardiovascular Diabetology·Diethelm TschöpePetra-Maria Schumm-Draeger
Aug 13, 2011·The Journal of Clinical Endocrinology and Metabolism·Mira AubuchonUNKNOWN Reproductive Medicine Network
Feb 18, 2014·The Journal of Clinical Investigation·Fleur LienPhilippe Lefebvre
Nov 20, 2012·Journal of Human Reproductive Sciences·Pratap Kumar, Kashif Khan
Jan 5, 2010·Medicina intensiva·S Olivera-GonzálezM E Navarro-Aguilar
Jan 29, 2009·Gastroenterología y hepatología·Gema de la Poza GómezDaniel Boixeda de Miquel
Feb 14, 2015·Frontiers of Medicine·Juan ZhengChaodong Wu
Oct 26, 2016·Toxicology and Applied Pharmacology·Xiaojiaoyang LiZhenzhou Jiang
Nov 7, 2016·Biochimica Et Biophysica Acta. Molecular Cell Research·Qi ChenYongsheng Chang
Jul 7, 2007·Critical Reviews in Toxicology·T WangH M Mehendale
Aug 22, 2018·Journal of Intensive Care Medicine·George Sam Wang, Christopher Hoyte

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