PMID: 9161472Jan 1, 1997Paper

Possible monocytic origin of chondrosarcoma: in vitro transdifferentiation of HLA-DR blood monocyte-like cells from a patient with chondrosarcoma, into neo-fibroblasts and chondrocyte-like cells

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
M L LabatP Strauss

Abstract

Nodules and multilayered areas composed of fibroblasts and chondrocyte-like cells embedded in an abundant extracellular matrix appeared spontaneously in in vitro culture of mononucleated blood cells taken from a patient with chondrosarcoma. Using specific antibodies it was demonstrated that the neo-fibroblasts which developed in the culture resulted from a direct transdifferentiation of monocytes expressing HLA-DR specificity. The experiment was carried out twice, once before surgery and then two years later. In both cases the spontaneous transdifferentiation of HLA-DR monocytes into neo-fibroblasts was observed. Previously it was shown that normal monocytes were also able to give rise in vitro to neo-fibroblasts. However, the latter are normally rapidly destroyed by cell-cell contact with T-cells. Normal T-cells adhere to normal neo-fibroblasts by which they are finally engulfed. As a result, the neo-fibroblasts lose their fibroblastic shape, no longer adhere to their support and die. Therefore the abnormal proliferation and persistence of neo-fibroblasts in pathological situations such as the present case may result either from an intrinsic defect in monocytes, T-cells or both. The question is whether or not this transdiffere...Continue Reading

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·N S CunninghamA H Reddi
May 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M L LabatP Chandra
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Citations

Jul 13, 2004·Autoimmunity Reviews·Brandon P Reines
Apr 11, 2001·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M L LabatG Milhaud
Jun 7, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M L LabatP Boireau
Jun 8, 2001·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M L Labat
Apr 30, 1999·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M L Labat
Jul 13, 2005·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Liju YangEdward E Tredget
Feb 12, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Michel R HoenigJulie H Campbell
Dec 8, 2004·Stem Cells·Boon Chin HengEng Hin Lee

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