Possible prophylactic anti-excitotoxic and anti-oxidant effects of virgin coconut oil on aluminium chloride-induced Alzheimer's in rat models

Journal of Integrative Neuroscience
Badrah Saeed Ali Alghamdi

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease that affects an estimated 5.4 million people worldwide. However, there remains no curative treatment for the condition. Aβ and hyperphosphorylated tau accumulation are the main hallmarks of the disease; they interfere with glutamate uptake and mediate glutamate excitotoxicity, oxidative stress, inflammation and neurodegeneration. As virgin coconut oil (VCO) is well-known as an antioxidant and anti-inflammatory natural compound, the purpose of the present study was to assess the possible prophylactic effect of VCO on aluminium chloride (AlCl3)- induced AD in rat. Alzheimer was induced by intraperitoneal injections of aluminium chloride (AlCl3) for 45 days (40 ml/kg per day), and our results showed that oral administration of VCO (5 ml per day for 30 days) prior to the administration of AlCl3 significantly reduced the glutamate level in both the hippocampus and prefrontal cortex compared to an VCO non-administrated AD group. Moreover, VCO significantly increased the glutathione (GSH) level in both the hippocampus and cortex and significantly decreased the malondialdehyde (MDA) level in only the cortex of the AlCl3-induced AD rat model compared to an AlCl3-induced...Continue Reading

References

Sep 1, 1994·Neurochemical Research·L Balazs, M Leon
Aug 13, 1998·Journal of Neural Transmission. Supplementum·H Braak, E Braak
Oct 2, 2001·Archives of Medical Research·R B MaccioniL Barbeito
Mar 21, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Arezoo Campbell
Sep 16, 2003·International Journal of Geriatric Psychiatry·Paul T Francis
Jul 6, 2004·Neurochemistry International·Matthew R HyndPeter R Dodd
Aug 27, 2004·Clinical Biochemistry·K G Nevin, T Rajamohan
Jul 29, 2006·Journal of Alzheimer's Disease : JAD·Xiongwei ZhuMark A Smith
Nov 3, 2006·Nature Reviews. Drug Discovery·Debby Van Dam, Peter Paul De Deyn
Dec 7, 2007·Experimental Neurology·Kodeeswaran ParameshwaranVishnu Suppiramaniam
Sep 11, 2008·Journal of Alzheimer's Disease : JAD·Inês BaldeirasCatarina Resende Oliveira
Mar 25, 2009·Antioxidants & Redox Signaling·Silvia Sorce, Karl-Heinz Krause
Jul 22, 2010·Pharmaceutical Biology·S IntahphuakA Panthong
Apr 2, 2011·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Z A ZakariaK Long
Apr 5, 2011·Free Radical Biology & Medicine·Mubeen A Ansari, Stephen W Scheff
Jun 1, 2012·Journal of Alzheimer's Disease : JAD·Marco MatosPaula Agostinho
Aug 17, 2012·Journal of Psychiatry & Neuroscience : JPN·Timothy J RevettSatyabrata Kar
Aug 29, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Mouna Abdelrahman AbujaziaIma Nirwana Soelaiman
Aug 30, 2012·JAAPA : Official Journal of the American Academy of Physician Assistants·Larissa DeDea
Sep 25, 2012·Cold Spring Harbor Perspectives in Medicine·Frank M LaFerla, Kim N Green
May 31, 2013·Neuron·Sam Gandy, Frank L Heppner
Jul 19, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Badlishah Sham Nurul-ImanHj Mohd Saad Qodriyah
Nov 12, 2013·Environmental Toxicology and Pharmacology·Svetlana Vučetić-ArsićNataša D Petronijević
Nov 14, 2013·Acta Neuropathologica·Stefan ProkopFrank L Heppner
Feb 27, 2014·Nature Neuroscience·Wei Ji MaPaul M Bays
Mar 19, 2014·Nature Reviews. Neurology·V Hugh Perry, Clive Holmes
Dec 3, 2014·Experimental and Therapeutic Medicine·Swee Keong YeapKamariah Long
Feb 11, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Naiane F B AlvesValdir A Braga
Mar 27, 2015·Rejuvenation Research·Gao-feng ZengDe-Qiang Xiao
Apr 9, 2015·Pharmaceutical Biology·Yusof KamisahHj Mohd Saad Qodriyah
May 21, 2015·Nature Reviews. Neuroscience·Frank L HeppnerBurkhard Becher
May 23, 2015·The British Journal of Nutrition·W M A D B FernandoR N Martins

❮ Previous
Next ❯

Citations

Mar 24, 2020·Environmental Science and Pollution Research International·Md Ataur RahmanHyewhon Rhim
May 15, 2021·Degenerative Neurological and Neuromuscular Disease·Samah LabbanBadrah S Alghamdi
May 25, 2021·Food Science & Nutrition·Ya-Zhou LuXiao-Zhong Lan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here