PMID: 7526321Jun 1, 1994Paper

Possible protective immunity in human opisthorchiasis

Parasite Immunology
P S AkaiA D Befus

Abstract

Chronic infections with the liver flukes Opisthorchis viverrini and Clonorchis sinensis affect over 30 million people in southeastern Asia. With ongoing exposure, reinfection readily occurs following curative treatment and cumulative infections result in significant morbidity and a predisposition to cholangiocarcinoma. Though protective immunity has never been described in human opisthorchiasis, heterogeneity in worm burden occurs and a small number of exposed residents of endemic areas remain apparently uninfected. To explore the nature of this heterogeneity, we compared levels of serum antibody (Ab) to O. viverrini measured by an enzyme-linked immunosorbent assay in 83 stool egg-positive and 49 stool egg-negative residents of an O. viverrini-endemic area in Thailand. Compared to the egg-positive residents, the egg-negative group had significantly higher levels of immunoglobulin (Ig)G, IgA and IgM to adult worm homogenate (AWH) and total Ab to metacercaria homogenate (MH). Furthermore, immunoblot analyses revealed that a significantly higher proportion of sera from the egg-negative residents had IgA reactivity against a 38-kDa AWH antigen and IgM reactivity against carbohydrate epitopes of a 42-kDa AWH glycoprotein antigen. Th...Continue Reading

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Citations

Jan 22, 2008·Parasitology Research·Hongman ZhangSung-Tae Hong
Nov 30, 2000·Current Infectious Disease Reports·T R Hawn, E C Jong
Aug 1, 1995·International Journal for Parasitology·P S AkaiA D Befus
Nov 13, 2003·Acta Tropica·S WongratanacheewinS Sirisinha
Jan 22, 2008·World Journal of Gastroenterology : WJG·Natthawut KaewpitoonBanchob Sripa
Jul 19, 2011·Parasitology International·Md Hafiz UddinSung-Tae Hong
Sep 27, 2005·Memórias do Instituto Oswaldo Cruz·Fu Shi QuanHun Mo Yang
Apr 22, 2021·Transactions of the Royal Society of Tropical Medicine and Hygiene·Weeraya PhupiewkhamWanchai Maleewong

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