Possible Relations Between Epstein-Barr Virus Past Infection and Classic Multiple Sclerosis in Guilan, Iran

Jundishapur Journal of Microbiology
Hamidreza HonarmandAli Roudbary

Abstract

Multiple sclerosis (MS) is a demyelinating condition affecting the central nervous system. Although the cause of this condition is unknown, patients with MS seem to have genetic vulnerability to certain environmental factors such as infection that could trigger this condition. We conducted this study to determine whether MS risk increases following primary infection with Epstein-Barr virus (EBV) and also to investigate any association between MS and seropositivity to anti-EBNA-1 IgG, anti-EBV-CA IgG, and anti-EBV-EA. EBV infection was confirmed using the Enzyme-Linked Immunoassay in the patient (n = 46) and control (n = 46) groups via commercial assays (anti-EBNA-1 IgG, anti-EBV-CA IgG, and anti-EBV-EA kits). The data were analyzed by using three statistical tests (Pearson chi-square, Spearman rho correlation, and odds ratio). Seropositivity to anti-EBNA-1 IgG did not show a significant difference between the patient and control groups (92.9% and 88.4%, respectively), and nor was seropositivity to anti-EBV-CA IgG different between the two groups (95.2% and 95.3%, consequently). The anti-EBV-EA-D test was negative in all the patients and in 95.3% of the controls. Seropositivity to both anti-EBNA-1 and anti-EBV-CA indicating past...Continue Reading

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Citations

Aug 19, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Zhe WangXiaoli Yu
Dec 19, 2018·Molecular Immunology·Elie DeebaChristina Christodoulou

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