Possible relationship between heat shock protein 70, cardiac hemodynamics, and survival in the early period after heart transplantation

Transplantation
H A BabaM C Deng

Abstract

Heat shock proteins (HSPs) are produced by cells in response to a wide variety of stresses. To determine a possible relationship between hemodynamic parameters and HSP 70 in the early postoperative period after heart transplantation, we examined immunohistochemically the inducible HSP 70 (anti-HSP 72) response in human heart biopsies, as well as the effect of myocardial rejection on HSP. A total of 105 routinely processed endomyocardial biopsies from 15 consecutive patients who underwent heart transplantation were examined. Analysis of hemodynamic and echocardiographic parameters were performed within 30 min and 12 hr after the biopsies. Immunohistochemically detected inducible HSP 70 was mainly located in the cytoplasm and nucleus/nucleolus of cardiomyocytes. Two specimens additionally showed HSP 70-positive interstitial cells and smooth muscle cells of arteries, whereas lymphocytes were consistently negative. There was a significant relation between the echocardiographically determined increased relaxation time and positive HSP 70 staining (P < 0.011). Patients with elevated right atrial pressure (P < 0.098), as well as those with increased left ventricular end systolic diameter (P < 0.06), showed a trend to higher HSP expres...Continue Reading

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Citations

Sep 12, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Daniela GiannessiAndrea Biagini
Nov 24, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·H A BabaM C Deng
Jul 18, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Mohamad H YamaniJames B Young
Jul 29, 2004·Transplantation·Thomas MuellerChristoph Aufricht
Sep 10, 1999·Annals of Medicine·M Jäättelä
Jun 25, 2008·Toxicon : Official Journal of the International Society on Toxinology·T C ConteE H Miyabara
Nov 18, 2005·American Journal of Physiology. Cell Physiology·Elen H MiyabaraRuben Mestril
May 23, 2017·The Journal of Clinical Investigation·Jamie L Todd, Scott M Palmer
Jul 6, 2021·Frontiers in Cardiovascular Medicine·Graham ChakafanaKaren Sliwa

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