Possible relationship between the COMT gene ValMet polymorphism and psychometric IQ in girls of the Qinba region in China

Neuropsychobiology
Kejin ZhangFuchang Zhang

Abstract

Catechol-O-methyltransferase (COMT) gene was hypothesized to have a relationship with human prefrontal cortex (PFC) function and individual cognitive abilities. The object of this study was to investigate the possible impact of genotypes of COMT Val158Met polymorphism on cognitive ability among children living in the Qinba region in China. A total of 305 children were included, 163 girls and 142 boys; both complete IQ evaluation and Val158Met genotyping results were obtained. The quantitative traits of psychometric IQ were calculated by using the Chinese Wechsler Intelligence Scale for Children. All subjects' genotypes of COMT gene Val158Met polymorphism were identified with the restriction fragment length polymorphism method. The F test showed that the average scores (including the Full Scale IQ, Verbal Scale IQ, Performance Scale IQ and three index scores) did not significantly differ among different groups defined by Val158Met genotypes, neither in boys nor in the total group (p > 0.05). There was a significant difference between the average of Freedom from Distractibility score among different genotypes found in girls (p = 0.033). Our results indicate that COMT gene Val158Met polymorphism may be related to the intelligence ...Continue Reading

References

Jan 1, 1981·American Journal of Medical Genetics·R S Spielman, R M Weinshilboum
Nov 21, 1996·Biochemical and Biophysical Research Communications·F HodaD A Collier
May 16, 1998·BMJ : British Medical Journal·T V Perneger
Mar 17, 2000·Brain Research. Brain Research Reviews·P S Goldman-RakicG V Williams
Jul 21, 2000·Science·J DuncanH Emslie
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·M F EganD R Weinberger
Feb 13, 2002·Behavior Genetics·K I Morley, G W Montgomery
Feb 19, 2002·The European Journal of Neuroscience·Marko HuotariPekka T Männistö
Apr 2, 2002·The American Journal of Psychiatry·Anil K MalhotraDavid Goldman
Jun 20, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Thalia C EleyIan Craig
Jul 10, 2004·Trends in Cognitive Sciences·Terry E Goldberg, Daniel R Weinberger
Apr 9, 2005·Annals of the New York Academy of Sciences·Jan VolavkaKaren Nolan
Jun 21, 2005·Journal of Psychiatric Research·Mao-Liang Chen, Chia-Hsiang Chen
Feb 16, 2006·Biological Psychiatry·Elizabeth M TunbridgeDaniel R Weinberger
Mar 3, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Wendy R KatesRobert J Shprintzen
May 27, 2006·Brain Research·Vincenzo De LucaJames L Kennedy
Oct 13, 2006·Neuroscience Letters·Ruth O'HaraJoachim Hallmayer

❮ Previous
Next ❯

Citations

Dec 23, 2009·Neuroscience and Biobehavioral Reviews·Dustin WahlstromMonica Luciana
Nov 19, 2015·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Koji ShimadaAkemi Tomoda
Oct 16, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Shihua ZhangXia Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.