Mar 1, 1975

Possible relationship of poly(A) shortening to mRNA turnover

Proceedings of the National Academy of Sciences of the United States of America
D SheinessJ E Darnell


Whereas the original size of poly(A) in HeLa cells is about 200 nucleotides, at steady state most of the poly(A) in mRNA contains less than 50 nucleotides. An endonucleolytic attack on poly(A) is suggested as the most likely method to accumulate short pieces of poly(A). Both poly(A) shortening and mRNA turnover appear to be inhibited by emetine, a drug that stops translation. It is possible that a random endonucleolytic attack leads to scission of poly(A) to a size below which the mRNA is unstable.

Mentioned in this Paper

Emetine Dihydrochloride
Biochemical Turnover
HeLa Cells
Poly(A) Tail
Adenine Nucleotides

About this Paper

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