Possible risk of endometriosis for Seveso, Italy, residents: an assessment of exposure to dioxin

Environmental Health Perspectives
F Y Bois, B Eskenazi

Abstract

A recent study by Rier et al. showed that rhesus monkeys exposed daily for 4 years to 5 or 25 ppt of dioxin in food develop endometriosis, with incidence and severity related to dose. We aimed to determine whether the total time-integrated dioxin exposure of a human population could be comparable to that of Rier's monkeys. We selected a sample of residents of Seveso, Italy, who were acutely exposed to high levels of dioxin following an accident in 1976. We conducted a toxicokinetic analysis which takes into account species and exposure differences in dose and timing between humans and monkeys. The area under the time-concentration curve for dioxin in fat, which corresponds to cumulative exposure over time, ranges for some of the most heavily exposed Seveso residents from approximately 1.7 x 10(6) ppt-days to 1.1 x 10(8) ppt-days. These values exceed in all cases the values for the monkeys exposed to 25 ppt or 5 ppt. Given their exposure, the Seveso population should be an ideal epidemiologic cohort to rule out or confirm whether exposure to dioxin leads to an increased risk of endometriosis in humans.

References

Apr 11, 1991·Journal of Toxicology and Environmental Health·P MocarelliV Carreri
Nov 1, 1993·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·S E RierJ L Becker

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Citations

May 26, 1998·Environmental Health Perspectives·J A GrassmanG W Lucier
Jul 16, 2002·Environmental Health Perspectives·Brenda EskenaziPier Mario Gerthoux
Nov 18, 2008·Gynécologie, obstétrique & fertilité·E DaraïM Ballester
Nov 17, 2007·Chemosphere·Jean-François HeilierDominique Lison
Jun 7, 2005·FEMS Microbiology Letters·Kunichika NakamiyaMasatoshi Morita
Oct 6, 2000·Andrologia·S SignoriniP Mocarelli
Jul 13, 2007·Current Opinion in Obstetrics & Gynecology·Emile DaraïGil Dubernard
Jan 28, 1999·The Journal of Biological Chemistry·M S RicciW A Toscano
May 1, 2021·International Journal of Molecular Sciences·Li-Hsuan WangKuo-Hu Chen
Apr 15, 1999·Fertility and Sterility·S A TreloarN G Martin
Aug 28, 2021·International Journal of Molecular Sciences·Laura GaspariSamir Hamamah

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