PMID: 176592Mar 11, 1976

Possible role for cyclic nucleotides and phosphorylated membrane proteins in postsynaptic actions of neurotransmitters

Nature
P Greengard

Abstract

The postsynaptic actions of some neurotransmitters may be mediated through cyclic nucleotides and cyclic nucleotide-dependent phosphorylation of specific membrane proteins in postsynaptic cells. In addition to providing a molecular basis for the actions of several neurotransmitters and of certain drugs affecting behaviour, the model suggests a mechanism by which neurotransmitter signals may be converted into electrophysiological responses in postsynaptic cells.

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Related Concepts

Cyclic AMP, (R)-Isomer
Intropin
Autonomic Ganglion
Cyclic GMP
Tissue Membrane
Smooth Muscle
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Permeability
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