Possible role for glutathione-S-transferase in the oligozoospermia elicited by acute zearalenone administration in Swiss albino mice

Toxicon : Official Journal of the International Society on Toxinology
Silvana Peterini BoeiraAna Flávia Furian

Abstract

Zearalenone (ZEA) is a non-steroidal estrogenic mycotoxin produced by several species of Fusarium, commonly found in the soil in temperate and warm countries and is a frequent contaminant of cereal crops worldwide. Accordingly, it has been implicated in several mycotoxicosis in farm animals and in humans, but the underlying mechanisms remain largely unknown. Therefore, the current study was aimed to investigate the effect of an acute dose of ZEA (40 mg/kg, p.o.) on reproductive and hematological parameters, as well as on markers of oxidative stress in liver, kidney and testes in mice. Adult Swiss albino male mice were exposed to a single oral administration of ZEA, and 48 h thereafter behavioral and biochemical tests were performed. No differences in locomotor or exploratory activity were observed in the open-field test. On the other hand, ZEA increased the number of leukocytes, segmented neutrophils, sticks, eosinophils, monocytes and decreased platelets and lymphocytes number. Moreover, ZEA drastically reduced the number and motility of live spermatozoa. Additionally, while levels of thiobarbituric acid reactive substances (TBARS), non-protein thiols (NPSH) and ascorbic acid in liver, kidney and testes were not altered by ZEA...Continue Reading

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Citations

Feb 8, 2014·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Silvana Peterini BoeiraAna Flávia Furian
Feb 2, 2016·Epilepsy & Behavior : E&B·Cleide Correia de OliveiraMauro Schneider Oliveira
Feb 17, 2015·Chemico-biological Interactions·Silvana Peterini BoeiraAna Flávia Furian
Oct 21, 2016·Environmental Science and Pollution Research International·Miao LongJianbin He
Sep 30, 2021·Experimental and Therapeutic Medicine·Xiaoyuan XuLan Xu

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