Nov 25, 1978

Possible role for impaired renal prostaglandin production in pathogenesis of hyporeninaemic hypoaldosteronism

Lancet
L H NorbyW Flamenbaum

Abstract

A 57-year-old woman with hypertension and moderate renal insufficiency had chronic unexplained hyperkalaemia. Metabolic balance studies confirmed a diagnosis of hyporeninaemic hypoaldosteronism. Two observations suggested that impaired renal prostaglandin production contributed to the pathogenesis of the patient's disorder. Baseline renal-prostaglandin synthesis (as determined by urinary excretion of P.G.E and P.G.F) was was substantially depressed when compared with that in nine normal females. Infusion of low doses of P.G.A1 produced a significant increase in serum-aldosterone and urinary potassium excretion; it also led to a dramatic fall in blood-pressure and serum-potassium. It appears from these studies that a defect in renal prostaglandin synthesis has an important role in the pathogenesis of hyporeninaemic hypoaldosteronism.

  • References4
  • Citations15

References

Mentioned in this Paper

Metabolic Process, Cellular
Pathogenic Aspects
Aldosterone Measurement
Pathogenesis
Kidney Failure
Depressed - Symptom
Hypoaldosteronism
Diastolic Blood Pressure
Potassium
Hypoaldosteronism, Hyporeninemic

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