Possible role for the novel gasotransmitter hydrogen sulphide in erectile dysfunction--a pilot study

European Journal of Pharmacology
Balasubramanian SrilathaPhilip K Moore

Abstract

Penile erectile tissue is a highly vascularised smooth muscle which hitherto has been an unexplored target for the neuromodulatory effect of hydrogen sulphide. In this study, intracavernous injection of sodium hydrogen sulphide to primates resulted in significant increases in penile length and cavernous pressure. In another set of experiments, administration of DL-propargylglycine (inhibitor of cystathionine gamma-lyase) to rats resulted in significant reduction in cavernous nerve stimulation-evoked perfusion pressure. Our pilot experiment suggests a possible role for endogenous hydrogen sulphide in erectile physiopharmacology through facilitation of nerve-mediated penile tumescence; this is confirmed by the inhibitory effect of propargylglycine on the proerectile pathway.

References

Jul 19, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Weimin Zhao, Rui Wang
Oct 24, 2002·Molecular Neurobiology·Hideo Kimura
Oct 7, 2003·Annual Review of Neuroscience·Darren Boehning, Solomon H Snyder
Dec 16, 2003·Biochemical and Biophysical Research Communications·Hui YanChaoshu Tang
May 18, 2004·Biochemical and Biophysical Research Communications·Bin GengChaoshu Tang
Jun 12, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Youqin ChengRui Wang

❮ Previous
Next ❯

Citations

Jul 16, 2010·Journal of Cardiovascular Translational Research·Benjamin L Predmore, David J Lefer
Mar 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Roberta d'Emmanuele di Villa BiancaGiuseppe Cirino
Mar 22, 2012·Antioxidants & Redox Signaling·Benjamin Lee PredmoreGabriel Gojon
Jan 14, 2012·Current Opinion in Nephrology and Hypertension·Kenia Pedrosa NunesR Clinton Webb
Jun 11, 2014·Nature Communications·Nannan NingJingxin Li
Jan 8, 2011·Annual Review of Pharmacology and Toxicology·Ling LiPhilip K Moore
Aug 19, 2014·Cell and Tissue Research·M AckermannA L Piña
May 21, 2009·The Journal of Sexual Medicine·Balasubramanian SrilathaPhilip K Moore
Jul 28, 2007·The Journal of Sexual Medicine·Balasubramanian SrilathaPhilip K Moore
Apr 16, 2011·The Journal of Sexual Medicine·Roeswita Leono LiawP Ganesan Adaikan
Feb 7, 2012·Biochemical Pharmacology·Mehdi GhasemiAli R Mani
Sep 2, 2015·Nitric Oxide : Biology and Chemistry·Serap GurWayne J G Hellstrom
Feb 5, 2016·Clinical and Experimental Pharmacology & Physiology·Fatma Aydinoglu, Nuran Ogulener
Mar 26, 2014·British Journal of Pharmacology·G Yetik-AnacakN Murat
Apr 12, 2017·Antioxidants & Redox Signaling·Roberta d'Emmanuele di Villa BiancaRaffaella Sorrentino
Oct 12, 2018·International Journal of Impotence Research·Bedoor QabazardOludotun A Phillips
Apr 7, 2011·Nature Reviews. Urology·Roberta d'Emmanuele di Villa BiancaGiuseppe Cirino
May 6, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kenneth R Olson
Mar 30, 2012·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Balasubramanian SrilathaPhilip K Moore
Jul 20, 2010·The Journal of Pharmacy and Pharmacology·Yoshitaka HasegawaShoji Fukushima
Apr 9, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kyle L FlanniganJohn L Wallace
Jun 28, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Ryan C JupiterPhilip J Kadowitz
Jan 23, 2020·Cells·Armance GelaudeJean-François Bodart
Mar 5, 2011·Expert Review of Clinical Pharmacology·Benjamin L Predmore, David J Lefer
Mar 28, 2020·Oxidative Medicine and Cellular Longevity·Liren ZhongAnyang Wei
Nov 26, 2011·Expert Review of Clinical Pharmacology·Xiao-Yan ZhuXin Ni
Jul 28, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bedoor QabazardOludotun Adebayo Phillips
Nov 8, 2017·Chemical Reviews·Milos R FilipovicRuma Banerjee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biosynthetic Transformations

Biosyntheic transformtions are multi-step, enzyme-catalyzed processes where substrates are converted into more complex products in living organisms. Simple compounds are modified, converted into other compounds, or joined together to form macromolecules. Discover the latest research on biosynthetic transformations here.

Related Papers

The Journal of Sexual Medicine
Balasubramanian SrilathaPhilip K Moore
Proceedings of the National Academy of Sciences of the United States of America
Roberta d'Emmanuele di Villa BiancaGiuseppe Cirino
The Journal of Sexual Medicine
Balasubramanian SrilathaPhilip K Moore
American Journal of Physiology. Heart and Circulatory Physiology
Youqin ChengRui Wang
© 2021 Meta ULC. All rights reserved