PMID: 6253364Aug 1, 1980

Possible role of a defect in hepatic bilirubin glucuronidation in the initiation of cholesterol gallstones

Gut
P DuvaldestinP Berthelot

Abstract

Abnormally low activity of hepatic bilirubin UDP-glucuronosyltransferase was found in 25% of 81 unselected patients with gallstones, as compared with only 3% in 35 controls. At the time of cholecystectomy, the stones were taken for analysis in 48 of 81 patients, and a bile sample was obtained in 42 of them. Among the stones, 75% were cholesterol stones, 15% pigment stones, and 10% 'intermediate' stones. Low hepatic conjugating activity was not preferentially associated with a given type of stone. No relation was found between the enzymic deficiency and the biliary cholesterol saturation index. A high proportion of biliary bilirubin monoglucuronide (over 40%) was found in four of seven patients with low transferase activity, as was earlier demonstrated in patients with overt Gilbert's syndrome. Raised biliary bilirubin monoglucuronide was also found in three patients, out of 46, who had normal transferase but raised biliary beta-glucuronidase activity. There was no evidence that deficient bilirubin conjugation could be a consequence of gallstones: the activity of another hepatic microsomal enzyme, glucose 6-phosphatase, taken as a reference, was measured in 12 patients and was always normal. Taking into account the very high fre...Continue Reading

References

Mar 28, 1975·Biochimica Et Biophysica Acta·P DuvaldestinP Berthelot
Nov 1, 1973·The Journal of Clinical Investigation·R C DanzingerL J Schoenfield
Sep 1, 1972·The Journal of Clinical Investigation·J FeveryK P Heirwegh
Jun 1, 1973·The Journal of Clinical Investigation·R T HolzbachK Holan
Mar 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·E A Rodriguez GarayL S Morisoli
Oct 1, 1972·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·R L Bree, R E Flynn
Jul 1, 1970·Clinica Chimica Acta; International Journal of Clinical Chemistry·M BlackK P Heirwegh
Jan 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·F P Van RoyK P Heirwegh
Jun 5, 1969·The New England Journal of Medicine·M Black, B H Billing
Aug 1, 1959·Proceedings of the Society for Experimental Biology and Medicine·G JASMIN, P BOIS

Citations

Aug 1, 1987·Digestive Diseases and Sciences·H OyabuF Nakayama
Jan 1, 1989·Pharmacology & Therapeutics·B Burchell, M W Coughtrie
Jul 24, 1998·Mutation Research·G Cantelli-FortiM Paolini
Oct 26, 1999·Cancer Letters·M PaoliniG Cantelli-Forti
Feb 1, 2003·Environmental Toxicology and Pharmacology·Ron van der OostNico P E Vermeulen
Feb 15, 2002·British Journal of Haematology·Renzo GalanelloA Cao
Aug 2, 2003·Journal of Clinical Pathology·M K DuttR P H Thompson
Nov 19, 2010·World Journal of Gastroenterology : WJG·Ali EzerGokhan Moray
Mar 17, 2000·Scandinavian Journal of Gastroenterology·O SandstadM Osnes
Jan 24, 2013·Clinics and Research in Hepatology and Gastroenterology·M KrawczykF Lammert
Nov 22, 2008·European Journal of Haematology·Raffaella OrigaAntonio Piga
May 1, 1991·The Journal of Surgical Research·T H MagnusonH A Pitt
Jul 1, 1989·The Australian and New Zealand Journal of Surgery·L VitettaA Elzarka
Jul 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B DescosD Alagille
May 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B F Smith, J T LaMont
Jul 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B W TrotmanS E Bernstein
Mar 1, 1986·The British Journal of Surgery·M J Whiting, J M Watts
Jan 11, 2014·Molecular Aspects of Medicine·Vincent Zimmer, F Lammert
Aug 31, 2016·Radiation Protection Dosimetry·T Sanikidze, E Chikvaidze
Feb 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C A GoreskyG M Fried

Related Concepts

Biliary Sludge
Bilirubin, (4E,15E)-Isomer
Cholelithiasis
Epicholesterol
Glucosephosphatase
Liver
UDP-Glucuronic Acid 3-O-beta-D-Galactosyl-D-Galactose Glucuronosyltransferase

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
B W TrotmanS E Bernstein
Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre
Fehmi AtesIsmet Aydogdu
© 2021 Meta ULC. All rights reserved