PMID: 9531440Apr 8, 1998Paper

Possible role of cAMP, cGMP and [Ca2+]i during NANC relaxation in the cat airway smooth muscle

Journal of the Autonomic Nervous System
A ImotoY Ito

Abstract

To investigate the possible role of cyclic nucleotides and [Ca2+]i in non-adrenergic non-cholinergic (NANC) relaxations evoked by electrical field stimulation (EFS) in the cat airway, we studied the effects of specific phosphodiesterase (PDE) type IV or V inhibitors on the biphasic-NANC relaxations, the correlation between NANC relaxation and changes in intracellular levels of cAMP and cGMP ([cAMP]i and [cGMP]i), and measured changes in [Ca2+]i during the NANC relaxation. EFS (repetitive stimuli at 20 Hz, 1 or 4 ms pulse duration, 50 V) applied to the bronchial smooth muscle during contraction induced by 5-HT (10(-5) M) in the presence of atropine (10(-6) M) and guanethidine (10(-6) M) elicited biphasic NANC relaxations. Zaprinast (> 3 x 10(-7) M), a specific PDE type V inhibitor, preferentially enhanced the amplitude of the first component of the NANC relaxations. However, rolipram (> 3 x 10(-7) M) enhanced both the first and second component of the NANC relaxation to a similar extent. In the trachea, EFS evoked monophasic NANC relaxation accompanied by a concomitant accumulation of [cAMP]i and [cGMP]i. Pretreatment with rolipram (3 x 10(-6) M) enhanced the accumulation of [cAMP]i and amplitude of NANC relaxation evoked by EFS...Continue Reading

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Citations

Mar 1, 2012·American Journal of Veterinary Research·Anne A WooldridgeSharron R Barney
Dec 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·D N K SarmaSatish Rattan
Mar 31, 2000·Current Opinion in Pulmonary Medicine·M S Barnette, D C Underwood
Sep 14, 1999·The American Journal of Physiology·A UcJ L Conklin
Jul 21, 2000·Alimentary Pharmacology & Therapeutics·E A Shaffer

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