Possible role of connective tissue in epidermal neoplasia

The British Journal of Dermatology
E N Mitrani

Abstract

Interactions between epidermal cells have been defined within a proposed mathematical model of mammalian skin. Testing the model in a computer suggests that in highly proliferating conditions of the epidermis competition for cell space in the basal layer may be sufficient to generate considerable forces in the papillary dermis. Data shown from human and pig epidermal hyperplasia indicate that basal cells are submitted to considerable lateral forces and that these and not dermal hyperplasia are the forces responsible for the increasingly folded dermo-epidermal junction. When the model was examined in condition of persistently high mitotic rate it was found that it could remain stable only if new connective tissue synthesis was not induced by the developing papillary tension. This complex and counterproductive relationship that may occur between epidermis and dermis and its possible role in the development of neoplasia are discussed.

References

Feb 1, 1975·Biological Reviews of the Cambridge Philosophical Society·W S Bullough
Oct 1, 1977·The Journal of Investigative Dermatology·E A BauerA Z Eisen
Dec 1, 1978·The British Journal of Dermatology·W S Bullough, E N Mitrani
Apr 1, 1976·The British Journal of Dermatology·M DuffillS Shuster
Jun 1, 1976·The British Journal of Radiology·P R Burch
Apr 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·J A Smith, L Martin
Mar 1, 1973·The British Journal of Dermatology·R Marks, T Nishikawa
Jun 1, 1969·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F Seilern-AspangI Christian
Jun 1, 1959·Experimental Cell Research·H QUASTLER, F G SHERMAN
Jul 1, 1965·The American Journal of Anatomy·J P MARQUES-PEREIRA, C P LEBLOND

Citations

Jan 1, 1982·Archives of Dermatological Research·E N Mitrani, R Marks
Jan 1, 1981·Bio Systems·E N Mitrani
Dec 1, 1978·The British Journal of Dermatology·A H BayoumiR Marks
Nov 1, 1978·The British Journal of Dermatology·M G Davies, R Marks
Nov 1, 1982·Journal of the American Academy of Dermatology·S V PollackB V Jegasothy
Jun 1, 1985·Journal of Cutaneous Pathology·D H McGibbon
Dec 1, 1983·The British Journal of Dermatology·E N Mitrani
Feb 1, 1984·Journal of Cutaneous Pathology·S P Barton, R Marks
Jul 1, 1982·The British Journal of Dermatology·E N Mitrani
Dec 1, 1984·The British Journal of Dermatology·E N Mitrani

Related Concepts

Metazoa
Cell Density
Cell Motility
Cell Nucleus
Connective Tissue
Epidermis
Hyperplasia
M Phase, Mitotic
Skin
Malignant Neoplasm of Skin

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