Possible role of fatty acids in milk as the regulator of the expression of cytosolic binding proteins for fatty acids and vitamin A through PPARalpha in developing rats

Journal of Nutritional Science and Vitaminology
Kazuki MochizukiToshinao Goda

Abstract

Fatty acids in milk are thought to play an important role in intestinal maturation and gene expression in the postnatal small intestine. In this study, we determined the jejunal mRNA levels, in rats, of peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARdelta which are nuclear receptors for fatty acids. We also measured expression of their target genes during the postnatal period, namely liver type fatty acid-binding protein (L-FABP) and cellular retinol-binding protein, type II (CRBPII). The mRNA levels of PPARalpha, L-FABP and CRBPII, but not PPARdelta, gradually increased during the suckling period and then sharply declined to a low level at the end of the weaning period. Rat pups at 17 d of age, weaned to a high-fat diet, showed significantly greater mRNA levels of PPARalpha, L-FABP and CRBPII than those weaned to a low-fat diet. Oral administration of PPARalpha ligand, WY14,643 during four consecutive days of the weanling period caused a parallel increase in the mRNA levels of PPARalpha, L-FABP and CRBPII genes. Furthermore, caprylic acid and oleic acid, which are major components of fatty acids in milk, induced jejunal PPARalpha, L-FABP and CRBPII gene expression. Our results suggest that fatty acids in ...Continue Reading

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Citations

Dec 31, 2010·Molecular & Cellular Proteomics : MCP·Jenny HanssonMartin Kussmann
May 21, 2008·Journal of Nutritional Science and Vitaminology·Yuko OguraToshinao Goda
May 14, 2009·Journal of Nutritional Science and Vitaminology·Kazuki MochizukiToshinao Goda
Jan 8, 2015·Journal of Exercise Nutrition & Biochemistry·Sung Pil Ryu
May 30, 2020·Critical Reviews in Biochemistry and Molecular Biology·William S BlanerMarcin Golczak

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