PMID: 10527130Oct 20, 1999Paper

Possible role of growth hormone, IGFs, and IGF-binding proteins in the regulation of ovarian function in large farm animals

Domestic Animal Endocrinology
D SchamsW M Amselgruber

Abstract

The aim of the study and short review was to present evidence that growth hormone (GH), locally produced insulin-like growth factors (IGFs), and IGF-binding proteins (IGFBPs) may have an important role in the control of ovarian function. There is clear evidence for a distinct GH-receptor mRNA expression and protein production in follicles (oocytes and granulosa-cumulus cells) and corpus luteum (CL). In hypophysectomized ewes, GH and LH are necessary for normal CL development. IGF-1 mRNA in the follicles is expressed in theca interstitial cells (TIC) and granulosa cells (GC) with already higher levels in the TIC before follicle selection. In contrast, IGF-2 is mainly expressed in the TIC. The IGFR-1 mRNA is expressed in both the TIC and GC, with increasing levels in GC during the final development of dominant follicles. IGF-1 is a very potent stimulator of progesterone and oxytocin release in GC. IGFBP-1, -2, -3, -4, -5, and -6 have been isolated from follicular fluid or ovarian tissue. Studies indicate that IGFBP expression and production in the developing follicle is dependent on both cell type and follicle size and is regulated by IGF-1 and gonadotropins. The highest expression of IGF-1 and IGFR-1 mRNA was demonstrated during...Continue Reading

References

Jul 1, 1994·Journal of Reproduction and Fertility·W AmselgruberA Skottner

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Citations

Dec 29, 2010·Cell Stress & Chaperones·Alexander V Sirotkin, Miroslav Bauer
Dec 8, 2000·Advanced Drug Delivery Reviews·K D Rittenhouse, G M Pollack
Aug 2, 2003·Molecular and Cellular Endocrinology·Alexander V SirotkinJ Kotwica
Jul 27, 2002·Domestic Animal Endocrinology·M Mihm, E J Austin
Sep 22, 2009·BMC Genomics·Md Munir HossainDawit Tesfaye
Feb 18, 2004·The Journal of Reproduction and Development·Alexander V SirotkinPavel Sanislo
Jul 20, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Fiona H ThomasEvelyn E Telfer
Aug 16, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·A V SirotkinF Valenzuela
Mar 24, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·S LlewellynD C Wathes
Dec 5, 2000·Anatomia, histologia, embryologia·J Plendl
Nov 2, 2001·Anatomia, histologia, embryologia·G G KaiserG A Palma
Mar 8, 2008·Reproduction in Domestic Animals = Zuchthygiene·P LangendijkB Kemp
Jan 4, 2013·Reproduction in Domestic Animals = Zuchthygiene·H TanakaH Iwata
Jul 1, 2004·Reproduction in Domestic Animals = Zuchthygiene·D Schams, B Berisha
Sep 19, 2002·The Journal of Veterinary Medical Science·Victor Chisha ZuluYutaka Sawamukai
Aug 16, 2008·Domestic Animal Endocrinology·M A VelazquezD C Wathes
Mar 19, 2004·Biology of Reproduction·Varadaraj ChandrashekarAndrzej Bartke
Dec 13, 2006·Molecular Reproduction and Development·L T NicklinM G Hunter
Dec 31, 2010·Korean journal of pediatrics·Janardhan P BhattaraiMi Jung Park

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