PMID: 11330486May 2, 2001Paper

Possible role of hydroxyl radicals in the oxidation of dichloroacetonitrile by Fenton-like reaction

Journal of Inorganic Biochemistry
Ahmed M Mohamadin

Abstract

Dichloroacetonitrile (DCAN), is a member of haloacetonitrile group and detected in drinking water supplies as a by-product of chlorination process. The mechanism of DCAN-induced carcinogenesis is believed to be mediated by oxidative bioactivation of DCAN molecules. The present study was designed to investigate if reactive oxygen species (ROS), similar to that generated in biological systems, are capable of oxidative activation of DCAN. A model ROS generation system (Fenton-like reaction; Fe2+ and H2O2) that predominantly produces hydroxyl radical (OH*) was used. DCAN oxidation was monitored by the extent of cyanide (CN-) release. The results indicate that DCAN was markedly oxidized by this system, and the rate of oxidation was dependent on DCAN concentration. Four-fold increase in H2O2 concentration (50-200 mM) resulted in a 35-fold increase in CN- release. The rates of DACN oxidation in presence of various transition metals were in the following order; iron>copper>titanium. DCAN oxidation was enhanced significantly by the addition of vitamin C and sulfhydryl compounds such as glutathione, N-acetyl-L- cysteine, and dithiothreitol (10 mM) to 140, 130, 145 and 136% of control, respectively. Addition of H2O2 scavenger; catalase or...Continue Reading

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Citations

Dec 23, 2003·Toxicology Letters·Ashraf B Abdel-Naim, Ahmed M Mohamadin
Jun 1, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Fahad A Al-Abbasi
Nov 9, 2011·Toxicology Letters·Nadia M HamdyAshraf B Abdel-Naim
Jan 24, 2015·Toxicology and Industrial Health·Fahad A Al-Abbasi
Jun 14, 2006·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Snezana S MiticSnezana B Tosic

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