Possible role of Krüppel-like factor 5 in the remodeling of small airways and pulmonary vessels in chronic obstructive pulmonary disease

Respiratory Research
Kyoko AbeMasakazu Ichinose

Abstract

Small airway remodeling is an important cause of the airflow limitation in chronic obstructive pulmonary disease (COPD). A large population of patients with COPD also have pulmonary hypertension. Krüppel-like factor 5 (KLF5) is a zinc-finger transcription factor that contributes to tissue remodeling in cardiovascular diseases. Here, we evaluate the possible involvement of KLF5 in the remodeling of small airways and pulmonary vessels in COPD. Lung tissues were obtained from 23 control never-smokers, 17 control ex-smokers and 24 ex-smokers with COPD. The expression of KLF5 in the lung tissues was investigated by immunohistochemistry. We investigated whether oxidative/nitrosative stress, which is a major cause of the pathogenesis in COPD, could augment the production of KLF5. We examined the role of KLF5 in the stress-mediated tissue remodeling responses. We also investigated the susceptibility of KLF5 expression to nitrosative stress using bronchial fibroblasts isolated from the lung tissues. The expression of KLF5 was up-regulated in the small airways and pulmonary vessels of the COPD patients and it was mainly expressed in bronchial fibroblasts and cells of the pulmonary vessels. The extent of the KLF5 expression in the small a...Continue Reading

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Citations

Jan 20, 2017·Respiratory Research·Clara E Green, Alice M Turner
Feb 7, 2018·American Journal of Respiratory and Critical Care Medicine·Fernando J MartinezJadwiga A Wedzicha
May 3, 2019·Journal of Molecular Histology·Xi-Hui WangJian-Rong Liu
Feb 29, 2020·Cardiovascular Research·Kashif Rafiq ZahidDeming Gou
Feb 2, 2021·Journal of Cellular and Molecular Medicine·Jia LiMadhavi J Rane
Mar 14, 2021·The Journal of Allergy and Clinical Immunology·Ayobami T AkenroyeRasika A Mathias

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Methods Mentioned

BETA
electrophoresis
FCS
Assay
transfection

Software Mentioned

Quantity One
Graphpad Prism
StatView
Image J

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