Possible role of luteinizing hormone and follicle-stimulating hormone in modulating inhibin secretion and expression during the estrous cycle of the rat

Endocrinology
C RivierW Vale

Abstract

In the female rat, plasma immunoreactive inhibin alpha (irl alpha) levels show marked changes during proestrus and estrus. We investigated the modulating effect of LH and FSH on these changes by injecting the GnRH antagonist DNal-DCpa-DPal-Dpr-(Ac)Dal-Leu-Arg-Pro-Asn-NH2, with or without exogenous LH replacement. Administration of the antagonist at noon on proestrus abolished the primary (proestrus) LH and FSH surge and markedly reduced the secondary (estrus) FSH surge. This treatment also reduced the release of irl alpha normally measured during proestrus afternoon, and partially prevented the decrease in irI alpha secretion on proestrus evening. Exogenous LH injected at 1545 h on proestrus had no measurable effect on irI alpha or FSH levels in control rats; however, in antagonist-treated animals, it restored the secondary FSH surge to control values while augmenting the late proestrus fall in irI alpha. This suggests that the decrease in inhibin secretion measured after exogenous LH treatment represents the mechanism through which LH induced the secondary FSH surge in antagonist-blocked rats. We also used in situ hybridization techniques to examine the changes in the expression of inhibin subunits in the ovary at 0200 h on es...Continue Reading

Citations

Jun 1, 1996·Cellular and Molecular Neurobiology·M TébarJ E Sánchez-Criado
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·C Rivier
Oct 8, 2009·The Journal of Reproduction and Development·Qiang WengKazuyoshi Taya
Jan 1, 1994·Duodecim; lääketieteellinen aikakauskirja·J Toppari, A Kaipia
Aug 1, 1996·American Journal of Obstetrics and Gynecology·R R TekmalR S Schenken

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