PMID: 1197904Jan 1, 1975Paper

Possible role of magnesium loss in the pathogenesis of myocardial fiber necrosis

Recent Advances in Studies on Cardiac Structure and Metabolism
D LehrS Irene

Abstract

Cellular loss of Mg is associated with uncoupling of oxydative phosphorylation and disruption of Mg-dependent intra-mitochondrial enzyme systems. The link of Mg loss and its association with intracellular Ca accumulation in the pathogenesis of myocardial fiber necrosis (MFN) has been clearly established in dietary Mg deficiency. Rapid loss of myocardial Mg has been demonstrated also in acute hypoxic states and in patients succumbing to myocardial infarction. Evidence from this laboratory indicates that loss of myocardial Mg may be a basic biochemical denominator in the development of MFN of diverse etiology, initiating a stereotyped ionic disequilibrium which encompasses loss of inorg. P and K accumulation of Na and Ca. This applies to MFN elicited by NaH2PO4 loading of parathyroidectomized rats, by injection of cardiotoxic dosages of adrenergic amines or by ligation of coronary vessels. Prevention of myocardial Ca accumulation by prior parathyroidectomy, did not interefere with emergence of MFN nor did it obviate the Mg loss and the remaining electrolyte disturbances. These parallel findings with three unrelated models of MFN do not support the view of a determinant role of CA overload. Administration of Mg salts, on the other...Continue Reading

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