PMID: 11336989May 5, 2001Paper

Possible role of natural killer cells in negative selection of mutant lymphocytes that fail to express the human leukocyte antigen-A2 allele

Mutation Research
Y KusunokiDonald G MacPhee

Abstract

Increased frequencies of cells carrying mutations at several loci have been found in the blood cells of atomic-bomb (A-bomb) survivors upon testing four or five decades after the bombing. Interestingly, though, we have been unable to demonstrate any radiation-associated increases in the frequencies of mutant blood cells in which human leukocyte antigen (HLA)-A expression has been disrupted; this is true both of preliminary tests on the T cells of a small subset of A-bomb survivors and of the much more extensive study reported here in which we screened a much larger group of survivors for HLA-A2 loss mutations in B cells and granulocytes as well as in T cells. In attempting to explain our inability to detect any increases in HLA-A2-negative cell numbers in HLA-A2 heterozygous individuals exposed to A-bomb irradiation, we decided to test the hypothesis that HLA-A mutant lymphocytes might well have been induced by radiation exposure in much the same way as every other type of mutant we encountered, but may subsequently have been eliminated by the strong negative selection associated with their almost inevitable exposure to autologous natural killer (NK) cells in the bloodstream of each of the individuals concerned. We now report t...Continue Reading

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Citations

Feb 24, 2015·Acta Neuropsychiatrica·Ibrahim KaplanLeyla Çolpan
Jul 25, 2009·Journal of Cellular and Molecular Medicine·Konstantinos A PaschosNigel C Bird
Oct 1, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Konstantinos A PaschosNigel C Bird
Dec 18, 2010·Journal of Surgical Oncology·Mark P LeGolvan, Murray Resnick
Jan 15, 2002·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·D Preston

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