Possible role of neuraminidase in the pathogenesis of arteritis and thrombocytopenia induced in rats by Erysipelothrix rhusiopathiae

Pathology, Research and Practice
H NakatoH Mikawa

Abstract

The role of the neuraminidase produced by Erysipelothrix rhusiopathiae (E. rhusiopathiae) in the pathogenesis of arteritis and induced thrombocytopenia was examined using young and adult rats. There was a close correlation between bacterial invasion, desialation and cell infiltration in the common iliac artery. E. rhusiopathiae induced arteritis from the second and third day after inoculation with 3 X 10(8) viable bacteria in the young and adult rats, respectively. This delay with age was closely related to the increase of free sialic acid in the plasma. The sites invaded by E. rhusiopathiae coincided with the desialated lesions, and the bacteria invaded the periarterial region which was always accompanied by desialation when examined with FITC-conjugated peanut lectin. The free sialic acid in the plasma was, at least partly, considered to originate from the desialation of the arterial wall caused by E. rhusiopathiae. The platelet number decreased significantly after inoculation. The sialic acid content of the platelets prepared from circulating blood at 12 and 18 hours after inoculation showed a slight decrease and decreased further when the platelets were incubated with the bacteria. Platelets obtained from circulating blood ...Continue Reading

References

Jan 1, 1985·Experimental Pathology·H NakatoH Mikawa
Feb 1, 1972·British Journal of Haematology·J F MustardM A Packham
Jan 1, 1972·British Journal of Haematology·S I ChoiL J Jorney
Jan 1, 1971·Pathologia et microbiologia·H E Müller

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Citations

May 3, 2005·Veterinary Microbiology·Qinning WangThomas V Riley
Nov 1, 1996·International Journal of Dermatology·K TotemchokchyakarnS Puavilai
Sep 8, 2009·Veterinary Microbiology·Qinning WangThomas V Riley
Oct 1, 1989·Clinical Microbiology Reviews·A C Reboli, W E Farrar

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