Possible Role of Non-NMDA Receptor-Mediated Neurotransmission in Steroid-Induced and Preovulatory Gonadotropin Surges in the Rat

Molecular and Cellular Neurosciences
D W BrannV B Mahesh

Abstract

The purpose of the present study was to determine the role of non-NMDA receptor-mediated neurotransmission in the expression and production of the progesterone-induced gonadotropin surge in the estrogen-primed ovariectomized adult rat and the preovulatory gonadotropin and prolactin (PRL) surges in the PMSG-primed immature rat. Adult female rats (45 days old) ovariectomized for 2 weeks were implanted with a third ventricular cannulae 1 week before the experiment. Estradiol (5 mug) was injected subcutaneously (sc) at 1700 h on Days 59 and 60 and either vehicle or progesterone (0.5 mg/rat) injected at 0900 h on Day 61. Vehicle or the non-NMDA antagonist DNQX (20 nmol/10 mul) was administered via the third ventricle cannula at 0800 and 1030 h on Day 61. From 1200 to 1800 h on Day 61 blood samples were withdrawn hourly from jugular cannulas for serum LH and FSH measurements. DNQX treatment completely blocked the progesterone-induced LH surge. FSH secretion, on the other hand, was unaffected by DNQX treatment. To study the effect of DNQX on preovulatory gonadotropin and PRL secretion, 27-day-old female rats were implanted with a third ventricle cannulae followed by sc injection of PMSG (8 IU) at 28 days of age (0800 h). On Day 30, ei...Continue Reading

Citations

Aug 26, 2006·Peptides·Luciano Debeljuk, Mercedes Lasaga
Oct 27, 2011·American Journal of Physiology. Endocrinology and Metabolism·Virendra B Mahesh
May 1, 2001·The Journal of Comparative Neurology·O EyigorL Jennes
Oct 16, 2002·The Journal of Comparative Neurology·Maryvonne Warembourg, Daniele Leroy
Feb 9, 2020·Medical Hypotheses·Ying-Lin HuangGang Zhu

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