PMID: 11326430May 1, 2001Paper

Possible role of peripheral CD14low monocytes in the development of collagen-induced arthritis in cynomolgus monkeys (Macaca fascicularis)

Experimental Animals
K TeraoY Yoshikawa

Abstract

The changes in levels of peripheral major lymphocyte subsets were monitored with 10 adult cynomolgus monkeys (5 females and 5 males) during the 9 weeks after immunization with chick type-II collagen in Freund's complete adjuvant. Three females and 3 males developed overt arthritis determined by swelling of small joints and increase of plasma alkaline phosphatase as well as C-reactive protein. An increase of CD16+ NK cells was observed in four non-arthritis-developed monkeys (two females and two males). There was no significant difference in the fluctuation pattern of CD4+ T cell, CD8+ T cell and CD20+ B cell levels between arthritis-developed monkeys and non-developed ones. In addition, the percentages of CD45RA+ CD4+ T cells to total CD4+ T cells, CD28- CD8+ T cells to total CD8+ T cells, and IgD- B cells to total B cells did not significantly differ between them. On the other hand, a significant increase was demonstrated in CD14-positive cells at 3 weeks after immunization in only arthritis-developed monkeys regardless of sex. The expression of CD14 antigen on the surface of increased cells was low in comparison with those appearing in blood obtained before immunization. In addition, increased CD14low cells showed no response...Continue Reading

References

May 1, 1976·Arthritis and Rheumatism·N A AndriopoulosE L Bradley
Jan 1, 1991·Arthritis and Rheumatism·M CutoloS Accardo
Feb 1, 1990·Annals of the Rheumatic Diseases·M D Smith, P J Roberts-Thomson
Sep 21, 1990·Science·R R SchumannR J Ulevitch
Jun 1, 1989·Molecular and Cellular Biology·S A GregoryT S Edgington
Nov 14, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·K KaikitaS Nakamura
Mar 28, 1998·The Journal of Experimental Medicine·T AlonziG Ciliberto
Jul 15, 1998·Clinical Science·J S Gaston
Aug 11, 1999·Journal of Autoimmunity·S NedvetzkiD Naor

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