PMID: 6536894Jun 1, 1984Paper

Possible role of serotonin in the secretory activity of the subcommissural organ of the cat

Neuroscience Research
T SakumotoM Jouvet

Abstract

The possible role of serotonin (5-hydroxytryptamine, 5-HT) in the secretory activity of the subcommissural organ (SCO) was investigated in the cat by using 5-HT immunohistochemistry and Gomori's secretory staining technique. Administration of para-chlorophenylalanine, a potent inhibitor of 5-HT synthesis, was found to produce a marked decrease in both 5-HT-immunoreactive materials and secretory granules in the SCO. In contrast, administration of 5-hydroxytryptophan, an immediate precursor of 5-HT, to animals pretreated with para-chlorophenylalanine resulted in an increase in the amount of both secretory granules and 5-HT immunoreactivities in this circumventricular organ. These results strongly suggest that the secretory activity of the SCO of cats is regulated by 5-HT.

References

Jan 1, 1972·Zeitschrift für Zellforschung und mikroskopische Anatomie·J Leonieni, L Rechardt
Jan 1, 1972·Zeitschrift für Zellforschung und mikroskopische Anatomie·A BjörklundK A West
Apr 1, 1966·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R C Graham, M J Karnovsky
Aug 1, 1981·The Journal of Comparative Neurology·H KimuraE G McGeer

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Citations

Aug 24, 1984·Neuroscience Letters·M SallanonM Jouvet
Feb 15, 2001·Brain Research. Developmental Brain Research·A LaalaouiH Gamrani
Oct 8, 2004·Brain Research. Molecular Brain Research·Hans G RichterEsteban M Rodríguez
Mar 10, 2001·Microscopy Research and Technique·M Didier-BazèsM F Belin
Dec 6, 2006·New Solutions : a Journal of Environmental and Occupational Health Policy : NS·Supriya LahiriEphraim Massawe
Jan 1, 1989·International Journal of Colorectal Disease·J F Mayberry

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