Possible role of sulfhydryls in mucosal protection induced by aluminum hydroxide

Digestive Diseases and Sciences
I Szelenyi, K Brune

Abstract

The involvement of sulfhydryl-containing compounds was investigated in the cytoprotective effect of certain antacids against ethanol-induced gastric mucosal damage in the rat. Not only the protective effect of a sulfhydryl containing compound, N-acetylcysteine, was abolished after pretreatment with N-ethylmaleimide, but also the adaptive cytoprotection induced by 20% ethanol. Pretreatment of the animals with the cyclooxygenase inhibitor indomethacin or with the thiol reagent N-ethylmaleimide significantly diminished the cytoprotection evoked by aluminum hydroxide. However, the protective effect of aluminium hydroxide could only be totally abolished by pretreatment with the combination of indomethacin and N-ethylmaleimide. The present results suggest the additional role of sulfhydryl-containing compounds localized in the gastric mucosa in the cytoprotection induced by a mild irritant or by aluminium hydroxide and aluminium hydroxide-containing antacids as well.

References

Feb 1, 1984·Computer Programs in Biomedicine·S A Werness, D J Anderson
Apr 8, 1983·European Journal of Pharmacology·I SzelenyiH Engler
Oct 9, 1981·Science·S SzaboP W Frankel
Nov 1, 1980·Digestive Diseases and Sciences·T K Chaudhury, A Robert

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Citations

Nov 1, 1993·Digestive Diseases and Sciences·C A Gutiérrez-Cabano
Oct 1, 1988·Digestive Diseases and Sciences·S Evangelista, A Meli
Nov 1, 1990·Digestive Diseases and Sciences·H Vergin, C Kori-Lindner
Jul 1, 1988·Digestive Diseases and Sciences·I Szelenyi, K Brune
Jul 17, 1999·European Journal of Pharmacology·H MatsudaM Yoshikawa
Apr 1, 1989·The American Journal of Medicine·R T Schoen, R J Vender
Oct 1, 1989·Scandinavian Journal of Gastroenterology·C A Gutiérrez-Cabano
Jan 1, 1990·Scandinavian Journal of Gastroenterology. Supplement·A TarnawskiH Gergely
Jan 1, 1990·Scandinavian Journal of Gastroenterology. Supplement·G GasbarriniE Micaletti
Nov 30, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·L NagyS Szabo
Mar 1, 1989·Medical Toxicology and Adverse Drug Experience·S SzaboK D Rainsford

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