Possible roles and determinants of microchimerism in autoimmune and other disorders

Autoimmunity Reviews
Kakali Sarkar, Frederick W Miller

Abstract

Microchimerism is the presence of a low level of non-host stem cells or their progeny in an individual. The most common source of microchimerism is pregnancy. During pregnancy, bi-directional trafficking of hematopoietic cells occurs through the placenta and these microchimeric cells persist for decades after childbirth. A possible role of microchimerism in the pathogenesis of some (systemic sclerosis, systemic lupus erythematosus, primary biliary cirrhosis, autoimmune thyroid diseases and juvenile myositis) but not all autoimmune diseases has been suggested by recent studies. Contradictory reports exist regarding HLA allelic associations with persistent T lymphocyte microchimerism. Although much of the focus of past studies has been on microchimerism in the effector arm of the immune system, increasing evidence suggests that microchimeric cells may differentiate into many lineages in different tissues raising additional possible roles for these cells. The possibility of microchimerism in many organs should induce an exploration of how persistent mixtures of cells of different genetic backgrounds throughout the body may influence diverse physiologic processes during life. In the present review, we discuss possible influencing f...Continue Reading

References

Sep 1, 1983·American Journal of Reproductive Immunology : AJRI·I J WeilerR Sprenger
Dec 24, 1998·Lancet·S AractingiE D Carosella
Jul 8, 1999·The New England Journal of Medicine·E A CatlinH J Weinstein
Sep 18, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L Rubbia-BrandtA Hadengue
Nov 30, 2000·Journal of Hepatology·P A FanningE E Powell
Nov 1, 2001·Archives of Dermatological Research·T OhtsukaS Yamazaki
Nov 16, 2001·Rheumatology·C M ArtlettUNKNOWN Childhood Myositis Heterogeneity Collaborative Study Group
May 4, 2002·Annals of Epidemiology·Arti Parikh-PatelM Eric Gershwin
Oct 24, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kirby L JohnsonDiana W Bianchi
Nov 15, 2002·European Journal of Immunology·Monique GannagéSophie Caillat-Zucman
Dec 25, 2002·Human Reproduction Update·Sinuhe Hahn, Wolfgang Holzgreve
May 27, 2003·Autoimmunity·J Lee Nelson
Nov 13, 2003·Arthritis and Rheumatism·Kiarash KhosrotehraniDiana W Bianchi
Nov 15, 2003·Science·Shohta KodamaDenise L Faustman

❮ Previous
Next ❯

Citations

Oct 19, 2006·Rheumatology International·Paola CaramaschiLisa Maria Bambara
Apr 14, 2007·American Journal of Respiratory and Critical Care Medicine·Martha L BustosMoisés Selman
Jun 8, 2006·Biology Direct·James L Weber
Mar 3, 2010·Genome Medicine·Carlo SelmiM Eric Gershwin
Apr 18, 2007·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Olav LapaireWolfgang Holzgreve
Nov 27, 2015·Clinical Rheumatology·Greiciane Maria da Silva FlorimMario Abbud-Filho
Jun 19, 2012·Journal of Autoimmunity·Robert A Eisenberg, Charles S Via
Jun 23, 2009·Cancer Letters·Laura FugazzolaPaolo Beck-Peccoz
Aug 7, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Miho TanigawaNorio Miharu
May 30, 2008·Experimental Hematology·Gary L GilmoreJohn Lister
Jan 1, 2014·International Journal of Dermatology·Ruken AlpMehmet E Erdal
Nov 5, 2015·Biology of Sex Differences·Jessica E BrandtDeLisa Fairweather
Aug 21, 2010·American Journal of Obstetrics and Gynecology·Christianne J M de GrootNicole M Van Besouw
Nov 26, 2010·Orvosi hetilap·Gyula Richárd NagyJános Rigó
Apr 19, 2015·Arthritis Research & Therapy·Greiciane M S FlorimMario Abbud-Filho
Jun 13, 2012·Chimerism·Josep-Maria PujalAntoni Bayes-Genis
Sep 20, 2012·Clinical Epigenetics·Hasan OzkanNuray Duman
Dec 24, 2010·Nature Reviews. Endocrinology·Laura FugazzolaPaolo Beck-Peccoz
Mar 6, 2007·Nature Clinical Practice. Rheumatology·Mark Gourley, Frederick W Miller
Dec 18, 2009·Expert Review of Molecular Diagnostics·Josep-Maria Pujal
Dec 1, 2008·Obstetric Medicine·Keelin O'Donoghue
Jun 7, 2008·Experimental Biology and Medicine·Josep-Maria Pujal, David Gallardo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Related Papers

Clinica Chimica Acta; International Journal of Clinical Chemistry
C M Artlett
Proceedings of the National Academy of Sciences of the United States of America
Diana W BianchiM A DeMaria
© 2021 Meta ULC. All rights reserved