Possible roles for zinc in destruction of Trypanosoma cruzi by toxic oxygen metabolites produced by mononuclear phagocytes

Advances in Experimental Medicine and Biology
J M Cook-MillsP J Fraker

Abstract

The effects of a single nutrient deficiency on immune function is now most extensively characterized using the dietary zinc deficient murine model. Deficiencies in zinc have rapid adverse effects on host defenses of humans and rodents. This impaired defense seems to be, in part, the result of a reduction in number of lymphocytes available for surveillance since residual lymphocytes are able to carry out many normal functions. In vitro, the lymphocytes were able to proliferate at a normal rate as well as produce antibodies or interleukin 2 in response to mitogens or antigens even when cultured in autologous serum to reduce the possibility of restoration of zinc deficient functions. Conversely, mononuclear phagocytes (MNP) from deficient mice had a significantly reduced capacity to associate with and kill the parasite Trypanosoma cruzi (T. cruzi) which causes Chaga's disease. Moreover, indicating the specificity of the deficient function, a short incubation of ZnCl2 but not other metals completely restored the capacity of MNP from deficient mice to take up and kill T. cruzi. Dependency on H2O2 production by the MNP's oxygen burst for killing of T. cruzi.suggested that MNP from zinc deficient mice might produce smaller amounts of ...Continue Reading

Citations

Jan 1, 2010·Nutrition Reviews·Junaidah B BarnettSimin N Meydani
May 17, 2012·PloS One·Tor A StrandHalvor Sommerfelt
Jan 17, 2014·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Niranjan KumarVeer Singh Rathor
Jan 5, 2005·Journal of Leukocyte Biology·Joan M Cook-Mills, Tracy L Deem
Mar 6, 2010·The Proceedings of the Nutrition Society·Paul Kelly
Jul 4, 2008·Inflammopharmacology·F García-TamayoL I Terrazas-Valdés
May 10, 2000·The Journal of Nutrition·L Rink, H Kirchner

❮ Previous
Next ❯

Related Concepts