PMID: 1291Oct 1, 1975

Possible structural-functional organization of the system of local cerebral blood flow regulation

Fiziologicheskiĭ zhurnal SSSR imeni I. M. Sechenova
Iu E MoskalenkoA N Deriĭ


rCBF under normal conditions in the rabbit, cat, and monkey brain was found to have a spontaneous periodicity while rCBF responses to afferent flicker stimulation usually revealed a double-phasic fluctuative pattern. This suggests that the rCBF regulatory system consists of not less than two regulatory chains with different time constants, and a feedback. The data on cerebral vascular responses to microapplication of mCSF solutions with various pH, potassium and catecholamines concentrations, suggest that rapid regulatory chains may be conditioned by potassium and neurogenic vascular effects, while slow ones could be mediated by CO2 and related pH changes.

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