Possible survival benefits from zoledronic acid treatment in patients with bone metastases from solid tumours and poor prognostic features-An exploratory analysis of placebo-controlled trials.

Journal of Bone Oncology
R ColemanJean-Jacques Body

Abstract

Zoledronic acid (ZOL) is an important component of therapy for patients with metastatic bone disease (MBD) to reduce the risk of skeletal-related events (SREs). We evaluated overall survival (OS) in patients with MBD secondary to solid tumours included in placebocontrolled ZOL trials. Exploratory analyses were performed using databases from three randomised trials of ZOL versus placebo. 1126 patients (ZOL, n=731; placebo, n=395) with complete baseline data for 18 predefined parameters were evaluated for OS. Relative risks (RRs) with 95% confidence intervals were assessed using stratified and adjusted Cox regression models. Baseline covariates defining patient populations with significantly different effects of ZOL treatment on OS (identified by stepwise backward elimination) were included in multivariate models. Although OS was similar between the overall treatment groups, ZOL significantly improved OS in the subset of patients (n=423; 38%) with elevated baseline NTX (≥100 nmol/mmol creatinine; RR, 0.692; P=.0028). Notably, this effect was independent of SRE prevention. Additional covariates associated with OS benefits with ZOL (e.g., low albumin, SRE history, elevated lactate dehydrogenase, shorter cancer duration) were charac...Continue Reading

Citations

Nov 16, 2017·Calcified Tissue International·Rachelle W Johnson, Larry J Suva
Sep 29, 2019·Nature Communications·Ricardo Romero-MorenoLaurie E Littlepage
Feb 18, 2014·Breast Cancer Research : BCR·Tilman D RachnerLorenz C Hofbauer
Jun 28, 2017·European Journal of Cancer Care·Stella D'OronzoRobert Coleman
Aug 30, 2016·Healthcare·Mark F McCarty, James DiNicolantonio
Jan 27, 2017·Science Translational Medicine·Kelsi AndradeAlana L Welm
Jun 20, 2018·Bone·M C VlotA C Heijboer

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