Abstract
The effects of mode, sequence and interval of antibiotic exposure on the post-antibiotic effect (PAE) induced by rifampicin and tobramycin were studied using Escherichia coli ATCC 25922 as the test organism. In triplicate, baseline PAEs were evaluated by exposing E. coli to rifampicin and tobramycin individually and simultaneously for 1 h. PAEs were further assessed in a second study, with the organism exposed first to rifampicin for 1 h, followed by a second 1 h tobramycin exposure, commencing at the beginning, middle and end of the PAE phase induced by rifampicin. The third study was similar to the above, but with the sequence of the two antibiotics reversed, i.e. tobramycin then rifampicin. The PAE produced by simultaneous exposure of the combination showed an apparent additive interaction (PAE: 5.0+/-0.3 h) when compared with the PAE of individual antibiotics (rifampicin alone: 3.0+/-0.1 h; tobramycin alone: 1.5+/-0.1 h). However, an antagonistic interaction was observed in the second study, with a more pronounced degree of antagonism at the beginning, dissipating towards the end of the previous rifampicin PAE (PAE at the beginning: 2.6+/-0.3 h; the middle: 1.5+/-0.2 h; and at the end: 1.7+/-0.3 h). By subtracting the resid...Continue Reading
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