Post-cancer Treatment with Condurango 30C Shows Amelioration of Benzo[a]pyrene-induced Lung Cancer in Rats Through the Molecular Pathway of Caspa- se-3-mediated Apoptosis Induction: -Anti-lung cancer potential of Condurango 30C in rats

Journal of Pharmacopuncture
Sourav SikdarAnisur Rahman Khuda-Bukhsh

Abstract

The present investigation aimed at examining if post-cancer treatment with a potentized homeopathic drug, Condurango 30C, which is generally used to treat oesophageal cancer, could also show an ameliorating effect through apoptosis induction on lung cancer induced by benzo[a]pyrene (BaP) in white rats (Rattus norvegicus). Lung cancer was induced after four months by chronic feeding of BaP to rats through gavage at a dose of 50 mg/kg body weight for one month. After four months, the lung-cancer-bearing rats were treated with Condurango 30C for the next one (5(th)), two (5(th)-6(th)) and three (5(th)-7(th)) months, respectively, and were sacrificed at the corresponding time- points. The ameliorating effect, if any, after Condurango 30C treatment for the various periods was evaluated by using protocols such as histology, scanning electron microscopy (SEM), annexinV-FITC/PI assay, flow cytometry of the apoptosis marker, DNA fragmentation, reverse transcriptase-polymerase chain reaction (RT-PCR), immunohistochemistry, and western blot analyses of lung tissue samples. Striking recovery of lung tissue to a near normal status was noticed after post-cancerous drug treatment, as evidenced by SEM and histology, especially after one and tw...Continue Reading

References

Apr 12, 2002·BMC Complementary and Alternative Medicine·Surjyo Jyoti Biswas, Anisur Rahman Khuda-Bukhsh
Jan 22, 2005·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Jun 28, 2005·British Journal of Pharmacology·Maleppillil Vavachan VijayakumarManoj Kumar Bhat
Dec 3, 2005·Evidence-based Complementary and Alternative Medicine : ECAM·Anisur Rahman Khuda-BukhshBiswapati Mandal
Mar 16, 2006·Molecular and Cellular Biochemistry·Surajit PathakAnisur Rahman Khuda-Bukhsh
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Dec 16, 2011·Experimental Biology and Medicine·Debrup ChakrabortyAnisur Rahman Khuda-Bukhsh

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BETA
flow cytometry

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SPSS
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