PMID: 7545527Apr 1, 1995Paper

Post-capillary venules in the "milky spots" of the greater omentum are the major site of plasma protein and leukocyte extravasation in rodent models of peritonitis

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
N S DohertyA J Milici

Abstract

Intraperitoneal injection of inflammatory agents in the mouse and rat causes plasma protein and leukocyte extravasation into the peritoneal cavity. Following an intraperitoneal injection of zymosan A, the milky spots of the omentum were the only abdominal sites detected where intravenously administered Monastral Blue labeled interendothelial cell gaps responsible for plasma extravasation. In addition, when colored microspheres were intraventricularly administered to quantify blood flow, the omentum was the only abdominal organ which showed an increase in blood flow during zymosan A peritonitis. A combination of light and electron microscopy, plus measurement of myeloperoxidase activity (a marker of neutrophil accumulation) demonstrated that the omental milky spots are the major route through which leukocytes migrate into the peritoneal cavity. Identical structures in the pleura likewise are the sites of protein leakage into the pleural cavity. In contrast, selective sites of protein and cellular extravasation could not be detected in the synovial lining of the inflamed knee joint.

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Citations

Apr 24, 1999·Diseases of the Colon and Rectum·D P O'Leary
Mar 18, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Danielle CollinsDes C Winter
Feb 1, 2008·Clinics in Colon and Rectal Surgery·Rebecca L WiatrekHarry T Papaconstantinou
Nov 8, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mohammad ZareieJacob van den Born
Dec 2, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mohammad ZareieJacob van den Born
Apr 21, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mohammad ZareieJacob van den Born
Nov 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Emily K MaderKah-Whye Peng
Oct 28, 2008·European Journal of Pharmacology·Satyanarayana S V Padi, Shrinivas K Kulkarni
Jan 1, 2013·Tissue Barriers·Verena KüppersDörte Schulte
Aug 13, 2013·The American Journal of Pathology·Abigail L SedlacekEdith M Lord
Nov 4, 2016·Surgery Today·Yuji MiyamotoHideo Baba
Mar 5, 2004·The Journal of Pharmacology and Experimental Therapeutics·Keisuke TakeshitaFlorian Gantner
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Sep 15, 2020·The Journal of Trauma and Acute Care Surgery·Gary Alan BassCharles William Schwab
Sep 4, 2020·Journal of Leukocyte Biology·Mingyong LiuSelene Meza-Perez
Dec 1, 2001·Journal of the American Society of Nephrology : JASN·Liesbeth H P HekkingRobert H J Beelen

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