Post-cesarean delivery infectious morbidity: Focus on preoperative antibiotics and methicillin-resistant Staphylococcus aureus

American Journal of Infection Control
Andrea Ries ThurmanDavid E Soper

Abstract

Randomized controlled trials show that administering preoperative antibiotics prior to cesarean delivery (CD) significantly reduces the incidence of post-CD infectious morbidity. Methicillin-resistant Staphylococcus aureus (MRSA) has become prevalent in obstetrics and gynecology. The objective of this trial is to examine infectious morbidity in a clinical setting before versus after implementation of a preoperative antibiotic policy and, further, to describe the organisms cultured from CD wound infections. We used a retrospective chart review of women delivering by CD before and after implementation of preoperative antibiotic policy. Prior to instituting the preoperative antibiotic policy, the incidence of post-CD infectious morbidity was 20.7% and dropped to 8.5% after the policy was established (P < .001). Study cohorts were similar (P > .05) in several risk factors for infection. MRSA was the most common organism isolated from post-CD wound infections (18/34, 53%). Endomyometritis accounted for the majority of post-CD infections (143/191, 74.9%), and most infections occurred within 7 days of CD (170/191, 89.0%). The incidence of post-CD infectious complications decreased after a policy of administering preoperative antibioti...Continue Reading

References

Oct 9, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael W EllisClinton K Murray
Sep 2, 2005·Obstetrics and Gynecology·Vanessa R LaiblGeorge D Wendel
Aug 18, 2006·The New England Journal of Medicine·Gregory J MoranUNKNOWN EMERGEncy ID Net Study Group
Sep 2, 2008·Obstetrics and Gynecology·Andrea Ries ThurmanDavid E Soper

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Citations

Apr 23, 2016·The Journal of Perinatal & Neonatal Nursing·Jan M Kriebs
Aug 23, 2018·Obstetrics and Gynecology·UNKNOWN Committee on Practice Bulletins-Obstetrics
Aug 16, 2019·Clinical Microbiology Reviews·Linda P ArendsenAbdul H Sultan

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