Post-exercise carbohydrate and energy availability induce independent effects on skeletal muscle cell signalling and bone turnover: implications for training adaptation

The Journal of Physiology
Kelly M HammondJames P Morton

Abstract

Reduced carbohydrate (CHO) availability before and after exercise may augment endurance training-induced adaptations of human skeletal muscle, as mediated via modulation of cell signalling pathways. However, it is not known whether such responses are mediated by CHO restriction, energy restriction or a combination of both. In recovery from a twice per day training protocol where muscle glycogen concentration is maintained within 200-350 mmol kg-1 dry weight (dw), we demonstrate that acute post-exercise CHO and energy restriction (i.e. < 24 h) does not potentiate potent cell signalling pathways that regulate hallmark adaptations associated with endurance training. In contrast, consuming CHO before, during and after an acute training session attenuated markers of bone resorption, effects that are independent of energy availability. Whilst the enhanced muscle adaptations associated with CHO restriction may be regulated by absolute muscle glycogen concentration, the acute within-day fluctuations in CHO availability inherent to twice per day training may have chronic implications for bone turnover. We examined the effects of post-exercise carbohydrate (CHO) and energy availability (EA) on potent skeletal muscle cell signalling pathw...Continue Reading

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Citations

Feb 11, 2020·Frontiers in Endocrinology·Ida A HeikuraKathryn E Ackerman
Jan 20, 2021·International Journal of Sport Nutrition and Exercise Metabolism·Megan A KuikmanJamie F Burr
Oct 27, 2020·Medicine and Science in Sports and Exercise·Carl Langan-EvansJames P Morton
May 1, 2021·Nutrients·Barbara StrasserMartin Burtscher
May 23, 2021·International Journal of Sport Nutrition and Exercise Metabolism·Nicole C A StrockEmily A Ricker
May 12, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Javier T Gonzalez, Gareth A Wallis
Jun 4, 2021·The British Journal of Nutrition·Andy J King, Rebecca C Hall

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